Bimanual Motor Skill Learning in Acute Stroke

Over 3 consecutive days, the patients will be evaluated and will train on the rehabilitation robot REAplan® (http://www.axinesis.com/) to assess proximal bim-MSkL and on the manual dexterity tool Dextrain Manipulandum (https://www.dextrain.com/) to assess distal bim-MSkL.

For proximal bim-MSkL, patients will train over the 3 days on the serious game Circuit on the bimanual REAplan® and will be randomised to two different bimanual versions. By this means, the investigators will explore the components of bim-MSkL in acute stroke patients.

The motor skill learning setup (Circuit) that was developed and successfully used in healthy individuals and stroke patients has already been implemented in the REAplan® environment and will be used as innovative serious games based on a speed/accuracy trade-off (SAT), allowing a detailed analysis of motor skill learning components (speed, accuracy, SAT, movement smoothness, dynamics...). For the serious game Circuit, who based on motor skill learning, the subjects will have to practice a complex circuit and move a cursor as quickly and accurately as possible by controlling the handles of the robot with both arms.

For distal bim-MSkL, patients will train on a complex sequence of finger movements involving both hands. Each day, several successive repetitions of the sequence will be displayed, corresponding to one block. 3 to 6 blocks will be repeated, each separated by 30 sec of rest. After training on the third day, a new sequence will be repeated for 3 blocks to assess generalization.

To explore the role of different brain structures in bim-MskL, Voxel-based Lesion Symptom Mapping (VLSM) based on high-resolution brain magnetic resonance imaging (MRI) scans, will be used to analyse the relationship between tissue damage and proximal/distal bim-MskL scores on a voxel-by-voxel basis.

Diffusion Tensor Imaging (DTI) will quantify the integrity of several white matter tracts, allowing through correlation analyses to unveil the white matter tracts crucial to achieve proximal and/or distal bim-MskL.

In addition, several "classical" clinical scales and tests will be used to evaluate overall motor-sensory-cognitive functions.

In addition to the (sub)acute stroke patients, a group of healthy individuals who will not undergo MRI (n=60) will be enrolled as control group. Subjects in this group will also be randomized 1/1 in the two versions of the bimanual Circuit task on the REAplan® robot.

• Reaction time measured by the Dextrain Manipulandum [Срок оценки: change between baseline (Day 1) and after training (Day 3)]
• Rise time measured by the Dextrain Manipulandum [Срок оценки: change between baseline (Day 1) and after training (Day 3)]
• Coactivation measured by the Dextrain Manipulandum [Срок оценки: change between baseline (Day 1) and after training (Day 3)]
• Hold time measured by the Dextrain Manipulandum [Срок оценки: change between baseline (Day 1) and after training (Day 3)]
• Voxel-based Lesion Symptom Mapping (VLSM) [Срок оценки: Baseline]
• Diffusion Tensor Imaging (DTI) [Срок оценки: Baseline]
• Fugl Meyer Upper Extremity Test (FMA-UE) [Срок оценки: Day1]
• Arm Motor Ability (AMA) test [Срок оценки: Day 1]
• Montreal Cognitive Assessment (MoCA) [Срок оценки: Day 1]
• Fatigue Visual Analog Scale (VAS) [Срок оценки: Day 1]
• Shoulder Abduction Finger Extension (SAFE) test [Срок оценки: Day 1]
• Modified Ashworth Scale (mAS) [Срок оценки: Day 1]