Le French Gut: Characterization of Gut Microbiota Profiles in France
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: General Population. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Франция
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Le French Gut : the French Microbiota
Обзор
" The French Gut " is a national contribution aiming to collect 100,000 faecal samples and associated nutritional and clinical data by 2027. Le French Gut is initiated by MetaGenoPolis-INRAE, supported by INRAE with Prof. R. Benamouzig, (AP-HP) as principal investigator of the project. The main goal of this national trial is a better understanding of the observed heterogeneity between gut microbiome of healthy subjects, its connections with the diet and lifestyle, but also changes in gut microbiota associated with diseases (diabetes, obesity, allergies, cancer, Parkinson, Alzheimer…).
Подробное описание
At the 14th International Conference on Genomics (ICG-14), scientists from China, Sweden, Denmark, France and Latvia launched The Million Microbiome of Humans Project (MMHP) and agreed to collaborate on a large-scale microbial metagenomic project. The overarching goal is to build the world's largest database of human microbiota with one million microbial samples from the intestines, mouth, skin and reproductive system. Therefore, making it possible to characterize the microbiota of people according to age, gender, height, weight, etc.
As a founding member of the MMHP, INRAE will bring the French national contribution: 100 000 faecal samples and associated nutritional and clinical data from France, by 2027, through Le French Gut project. Initiated by the MGP research unit, Le French Gut is led by INRAE and the AP-HP (Public Assistance-Hospitals of Paris), with the support and collaboration of a consortium of members from medical, scientific and industrial sectors.
In order to be a participant of the project, volunteers will need to fill out an online questionnaire with 60 questions about their lifestyle, their dietary habits and their medical background. The second requirement is the stool sampling, at home.
Main scientific targets of this project are the following:
* Build a map of the intestinal microbiota in France, reflecting differences in term of gut microbiome through ages, gender, regions of life, diets, habits and medical status; * Describe and better understand the heterogeneity between gut microbiota of healthy subjects and investigate the connection between this heterogeneity with diet and habits. * Describe the variations of the intestinal microbiota associated with the presence and development of certain diseases (chronic diseases, neurodevelopmental disorders, neurodegenerative diseases,…)
Первичные конечные точки
- Characterize the heterogeneity and diversity of the gut microbiota of subjects living in France [Срок оценки: 5 up to 15 years]
Вторичные конечные точки (5)
- Study the variations in the gut microbiota as a function of microbial profile [Срок оценки: 5 up to 15 years]
- Study the variations in the gut microbiota as a function of age [Срок оценки: 5 up to 15 years]
- Study the variations in the gut microbiota as a function of socio-demographic and anthropometric characteristics [Срок оценки: 5 up to 15 years]
- Study the variations in the gut microbiota as a function of lifestyle and eating habits [Срок оценки: 5 up to 15 years]
- Study the variations in the gut microbiota as a function of presence of known pathologies at inclusion, occurrence during follow-up of certain pathologies identified by analysis of data from health from health questionnaires and SNDS data. [Срок оценки: 5 up to 15 years]
Критерии участия
Критерии включения
- Persons over the age of 18 living in France.
- Consent form signed electronically.
Non inclusion Criteria:
- Non-adult person (declarative);
- Person not living in France (declarative);
- Persons subject to a protective measure, in particular under guardianship or curatorship or unable to express their consent (declarative);
- Person having had a colectomy (declarative);
- Person with a digestive stoma (declarative);
- Person who has not signed the consent;
- Person who did not answer the entry questionnaire;
- Person who has not sent a compliant stool sample;
- Antibiotic intake in the 3 months before inclusion (declarative);
- Performing a colonoscopy in the 3 months preceding inclusion (declarative).
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Франция · 1 центр
- Centre de Recherche sur Volontaire — Bobigny
Публикации
- Connan C, Fromentin S, Benallaoua M, Alvarez AS, Pons N, Quinquis B, Morabito C, Nazare JA, Borezee-Durant E; Le French Gut Consortium; Haimet F, Ehrlich SD, Valeille K, Cavezza A, Blottiere H, Veiga P, Almeida M, Dore J, Benamouzig R. Associations Among Diet, Health, Lifestyle, and Gut Microbiota Composition in the General French Population: Protocol for the Le French Gut - Le Microbiote Francais PMID 40358997
Идентификаторы
NCT: NCT05758961 · 2021-A01439-32