Assessing the Dose-response of Muscle Protein Synthesis to "Super-whey" in Older Adults

Официальное название

Assessing the Dose-response of Muscle Protein Synthesis to "Super-whey" at Rest and in Response to Acute Exercise in Older Adults

Обзор

Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence. Undesirable loss of skeletal muscle mass (atrophy) is, however, a common feature of many diseases and scenarios including ageing, bed rest/immobilisation, cancer and physical inactivity. Despite the exact mechanisms causing muscle atrophy being not yet fully understood, "anabolic resistance" (reduced muscle building in response to protein feeding and exercise) is thought to be key, especially for age-related skeletal muscle losses (known as sarcopenia). As such, the search for optimal strategies (e.g., exercise and/ or nutritional interventions) to combat this anabolic blunting remains a hot-topic in scientific research. Leucine, an essential and branched chain amino acid (EAA/BCAA), is thought to be the most potent AA for stimulating muscle protein synthesis (MPS; the muscle building process). Although, as a stand-alone supplement, leucine is unlikely to provoke a robust and prolonged state of MPS, low doses of leucine-enriched mixed-EAAs can elicit similar increases in MPS as compared to a large dose of whey protein. As reduced appetite and increased satiety (feeling fuller) are common with advancing age, supplementation of a low-dose protein (i.e., leucine-enriched) that can adequately stimulate MPS may contribute to muscle health maintenance in older adults and reduce satiation following a meal. This study aims to examine which of three doses of a novel leucine-enriched whey protein ("super-whey") best stimulates muscle building in older adults

Вмешательства

• Другое Dietary protein supplement
  3 different doses of super-whey protein supplements will be given in a randomised crossover fashion to participants

Первичные конечные точки

• Muscle protein fractional synthetic rate (postabsorptive) [Срок оценки: Assessed at 3 hour mark]
• Muscle protein fractional synthetic rate (postprandial) [Срок оценки: Assessed at 6 hour mark]

Вторичные конечные точки (1)

• Plasma amino acid concentrations [Срок оценки: Assessed over 7.5 hours]

Критерии участия

Критерии включения

• Participant is in the desired age-ranges (young adults: 18-35 years; older adults: 65+ years).
• Participant is willing and able to give informed consent for participation in the study.
• Participant is physically able to perform resistance exercise

Критерии исключения

• A BMI <18 or >35 kg/m2
• Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP > 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent (6 mo) stroke
• Any metabolic disease
• Clotting dysfunction
• A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy)
• Lactose intolerance
• Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Двойное слепое

Основная цель

Другое

Центры проведения

Великобритания · 1 центр

• Centre of Ageing, Metabolism and Physiology — Derby

Идентификаторы

NCT: NCT05700058 · ARLA-WHEY_PtB_COMAP

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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