Идёт набор NCT05694624

Investigations Into Sepsis-associated Acute Kidney Injury

— Наблюдательное Acute Kidney Injury

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Para Aminohippurate.
Кому может быть актуально: Состояния в реестре: Acute Kidney Injury. Базовые параметры: 18 лет — 100 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Норвегия
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Investigations Into the Mechanisms for Bioenergetic Failure in Sepsis-associated Acute Kidney Injury

Обзор

In this study the investigators would like to study systemic and regional disturbances in patients with sepsis-associated acute kidney injury and in healthy controls undergoing laparoscopic abdominal surgery. Specifically study metabolic, hemodynamic and oxygen transport variables.

Подробное описание

Acute kidney injury (AKI) in patients with sepsis has a very poor prognosis with up to 60% mortality. The pathobiology remains to be fully understood. Creatine and phosphocreatine, products of arginine metabolism through L-arginine:glycine amidinotransferase (AGAT) and its sister enzyme guanidinoacetate N-methyl-transferase (GAMT), provide an energy-buffering system that is essential for intracellular adenosine triphosphate (ATP) supply. We hypothesized that sepsis associated AKI may be caused by failure of this energy-buffering system. In series of pilot studies, we explored metabolic and bioenergetic patterns in patients and animals with high risk of developing AKI. These data suggest that sepsis associated AKI may be caused by failure of this alternative renal energy source. In the current application we propose a clinical investigation of renal metabolism and renal bioenergetics in patients with high and low risk of developing sepsis associated AKI. The primary objective is to directly investigate renal AGAT activity through the arginyl metabolites homoarginine, guanidino acetate, and creatine. Secondary objectives are to study renal and systemic hemodynamics, renal oxygenation, glomerular filtration rate (GFR), renal tubular function, and mitochondrial respiration.

Вмешательства

Препарат Para Aminohippurate
Measurements of renal plasma flow and glomerular filtration rate

Первичные конечные точки

Hemodynamics [Срок оценки: Repeated measures at 10am, 12am, 2pm, 4pm,6pm, and 8pm]

Вторичные конечные точки (1)

Metabolic alterations [Срок оценки: Repeated measures at 10am, 12am, 2pm, 4pm,6pm, and 8pm]

Критерии участия

Inclusion Criteria sepsis group:

Sepsis diagnosed or suspected
Normal premorbid serum creatinine measured or anticipated (if data are not available)
Normovolemia as indicated by a pulse pressure variation less than 12%

Comparator group

Previously healthy individuals scheduled for laparoscopic colon cancer resection
Normal creatinine levels within 3 months before admittance to hospital.