Идёт набор NCT05683093

Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood

— Наблюдательное Young Adult Hypertension in Pregnancy Hypertension Cardiovascular Diseases

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: History of being born to hypertensive or normal pregnancy.
Кому может быть актуально: Состояния в реестре: Young Adult, Hypertension in Pregnancy, Hypertension, Cardiovascular Diseases. Базовые параметры: 30 лет — 40 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Великобритания
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Cardiovascular Longitudinal the Avon Longitudinal Study of Parents and Children (ALSPAC) Research Investigations Following Hypertensive Pregnancy in Young Adulthood

Обзор

The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.

Подробное описание

Women who develop blood pressure problems during pregnancy are more likely to have high blood pressure (hypertension) in later life as well as heart attacks or strokes. The children born to the pregnancy also tend to have higher blood pressure and are often at increased risk of heart and blood vessel disease later in life. Previous work has shown that children born to pregnancies where the mother has high blood pressure have changes in their blood vessels, heart and brain that can be measured long before they develop high blood pressure or other clinical symptoms. By understanding the pattern of changes cross multiple parts of the body, over a lifetime, the investigators can identify how advanced the underlying disease is for an individual and how their disease is likely to develop over the next few years.

The aim of this study is to understand the heart and blood vessel changes of people born to a hypertensive pregnancy once they are in their 20s and 30s. The investigators then hope to use this information to develop new ways to prevent early onset heart and blood vessel disease in these people.

Вмешательства

Другое History of being born to hypertensive or normal pregnancy
CLARITY is an observational study whereby participants will attend one 4-hr visit the Division of Cardiovascular Medicine, University of Oxford at the John Radcliffe Hospital in Oxford, with the option to split the study visit over two days for convenience. Participants will be invited by the ALSPAC study team to attend a study visit in Oxford where the investigators will use MRI and other imaging modalities to study the brain, heart, liver, kidneys, and vasculature using standardised protocols

Первичные конечные точки

Cardiac right ventricular mass [Срок оценки: 30-40 years of old]

Вторичные конечные точки (12)

Cardiac left ventricular mass [Срок оценки: 30-40 years of old]
Cardiac right ventricular end-diastolic volume [Срок оценки: 30-40 years of old]
Cardiac right ventricular stroke volume [Срок оценки: 30-40 years of old]
Cardiac left ventricular end-diastolic volume [Срок оценки: 30-40 years of old]
Cardiac left ventricular stroke volume [Срок оценки: 30-40 years of old]
Cardiac right ventricular systolic function [Срок оценки: 30-40 years of old]
Cardiac left ventricular systolic function [Срок оценки: 30-40 years of old]
Cardiac right ventricular diastolic function [Срок оценки: 30-40 years of old]
Cardiac left ventricular diastolic function [Срок оценки: 30-40 years of old]
Morphology of the right ventricles [Срок оценки: 30-40 years of old]
Morphology of the left ventricles [Срок оценки: 30-40 years of old]
Aortic compliance [Срок оценки: 30-40 years of old]

Критерии участия

Критерии включения

Participant is willing and able to give informed consent for participation in the study
Male or female, aged 30 to 40 years at time of enrolment
Participant previously took part in the ALSPAC study
Able (in the investigator's opinion) and willing to comply with all study requirements
Adequate understanding of verbal and written English

Критерии исключения

Pregnant or lactating when they are due to attend for study visit 1
Less than six months postpartum
Planning to donate blood within two weeks prior to study visit 1
Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study
Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status

For exclusion of MRI component only: