Role of Parent Interpretation Bias in the Transmission of Anxiety to Children

Официальное название

Parent Interpretation Bias as a Key Mechanism of Intergenerational Transmission of Anxiety

Обзор

Approximately 30% of children will experience an anxiety disorder, making anxiety the most common mental health problem among children in the United States. However, few children receive treatment and even our most effective anxiety treatments leave up to half of children in need of additional intervention. Despite the well-established role of parent anxiety in transmitting and maintaining child anxiety, the lack of data on specific parent mechanisms underlying the intergenerational transmission of anxiety is a critical barrier to informing novel targets of personalized treatments. Consistent with NIMH's Strategic Plan, Objective 2.2 to understand risk factors and behavioral indicators of mental illness across the lifespan and to identify novel intervention targets based on knowledge of psychological mechanisms, the current study focuses on interpretation bias, the tendency to perceive threat in ambiguous situations. The overall objective of this project is to empirically test a theoretical model of the intergenerational transmission of anxiety focused on parent interpretation bias as a root cause. Our specific aims are to test theorized effects of parent interpretation bias on (1) parent behavior and (2) child interpretation bias and (3) evaluate potential moderators to refine theories of intergenerational transmission of anxiety and inform future personalized interventions. Our central hypothesis is that parent interpretation bias influences child interpretation bias through its effects on maladaptive, anxiety-promoting parenting behaviors, such as accommodation and modeling of avoidant coping. To test this hypothesis, we will randomize 300 parents of children ages 7-12 to complete four weeks of a smartphone delivered interpretation bias manipulation vs. a self-assessment smartphone app condition. The interpretation bias intervention teaches parents to interpret ambiguous situations in a non-threatening manner via quick, repeated practice and corrective feedback. Before and after completing their randomly assigned condition, parent-child dyads will complete self-report and behavioral tasks designed to elicit anxiety-promoting behaviors from parents depending upon their interpretation of the ambiguous situation (speech and puzzle tasks). Parents will also complete Ecological Momentary Assessment (EMA) of parenting behaviors to capture the time course of effects. Finally, we will examine downstream effects of the interpretation manipulation on child interpretation bias at pre- and post- visits. We will test moderators (e.g., parent anxiety and gender) to refine theories of intergenerational transmission of anxiety and inform future personalized interventions. The long-term goal of this work is to inform personalized, mechanism-focused interventions to improve mental health outcomes for anxious children and their parents. Future studies will translate knowledge gained from this project into a scalable treatment that can be implemented entirely remotely via smartphone thereby increasing access to care

Вмешательства

• Поведенческое HabitWorks
  Smartphone app-delivered interpretation bias intervention
• Поведенческое Self-Assessment
  Self-assessment of parenting behaviors and anxiety symptoms

Первичные конечные точки

• Parent behavior [Срок оценки: 6 weeks]

Вторичные конечные точки (1)

• Child interpretation bias [Срок оценки: 6 weeks]

Критерии участия

Inclusion criteria for parent participants are:

• Must have an ability to speak and understand English sufficiently to complete assessments
• At least minimal anxiety severity (GAD-7 score > 5)
• At least a minimal level of interpretation bias (WSAP overall accuracy less than 70%)
• No current psychiatric symptoms that would interfere with the individual's ability to provide consent or complete the research procedures
• If receiving treatment, stable on medications or psychotherapy for 8 weeks
• No severe suicidal ideation (PHQ-9 item 9 > 1)
• Own iOS or Android smartphone
• Shared or full custody of child (for EMA assessment of parenting behaviors)

Inclusion criteria for child participants are:

• Age 7 to 12
• Must have an ability to speak and understand English sufficiently to complete assessments
• No diagnosis of intellectual disability or autism spectrum disorder (per parent or clinician report)
• No current psychiatric symptoms that would prevent informed consent or understanding of research procedures
• Wechsler Abbreviated Scale of Intelligence (WASI) full-scale IQ equal to or greater than 80 to ensure understanding of study procedures
• If receiving treatment, stable on medications or psychotherapy for 8 weeks
• No severe suicidal ideation (PHQ-9 item 9 > 1)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Простое слепое

Основная цель

Фундаментальное исследование

Центры проведения

США · 1 центр

• McLean Hospital — Belmont

Публикации

• Chiffer MA, Dickstein DP, Itkin-Ofer R, Kuckertz JM, Ren B, Shin DE, Silverman AL, Webb CA, Beard C. Protocol for the Parent Anxiety Transmission and Habits (PATH) study: a randomised controlled trial testing parent interpretation bias as a key mechanism of intergenerational transmission of anxiety. BMJ Open. 2026 Jul 22;16(7):e119801. doi: 10.1136/bmjopen-2026-119801. PMID 42486525

Идентификаторы

NCT: NCT05665491 · 2022p003245

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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