Идёт набор NCT05519735

Lymphatic Organs and Myocardium After Myocardial Infarction

Без фазы С лечением Myocardial Infarction Myocardial Injury Myocardial Inflammation

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Multimodality Imaging.
Кому может быть актуально: Состояния в реестре: Myocardial Infarction, Myocardial Injury, Myocardial Inflammation. Базовые параметры: 18 лет — 90 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Германия
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Multimodal Characterization of Lymphatic Organs and Myocardium in Patients After Acute Myocardial Infarction

Обзор

The adaptive immune response plays an important role in myocardial healing and remodeling after acute myocardial infarction in patients. Therefore, the involved lymphocytes represent a novel target for therapeutic interventions. However, there are no established blood-derived biomarkers to predict the quantity and quality of the adaptive immune response to cardiac injury. Multimodal imaging of the heart and immunologic organs might provide such information. Recent retrospective analysis of patients after MI revealed enlarged mediastinal lymph nodes associated with increased CXCR4 radiotracer accumulation, thereby indicating that CXCR4 PET-based lymph node imaging provides a non-invasive quantitative readout of the local adaptive immune response. These considerations are further fuelled by the fact that, within lymph nodes, CXCR4 is expressed almost exclusively on lymphocytes, whereas various other cell types express CXCR4 within the myocardium. This leads to the hypothesis that the size of mediastinal lymph nodes and their respective CXCR4 PET signals correlate with the adaptive immune response to cardiac injury and might provide predictive information for functional cardiac decline during follow-up. This prospective clinical study will use multimodal imaging to monitor chemokine receptor 4 (CXCR4) expression in the lymph nodes, myocardium, spleen, and bone marrow after acute MI. The combination of cardiac magnetic resonance (CMR), echocardiography, and positron emission tomography (PET) along with blood collection for immunophenotyping will allow to determine i) if the size of mediastinal lymph nodes and their respective PET-derived CXCR4 signals at baseline correlate with the adaptive immune response to acute cardiac injury; and ii) if they predict cardiac adverse remodelling during longitudinal follow-up.

Вмешательства

Диагностический тест Multimodality Imaging
Patients receive CXCR4-targeted PET/CT, CMR and Echo

Первичные конечные точки

CXCR4 PET-derived uptake after myocardial infarction [Срок оценки: 12 months]

Вторичные конечные точки (4)

Correlation of quantitative parameters (SUV) with peripheral lymphocytes [Срок оценки: 12 months]
Time course of SUV after myocardial infarction [Срок оценки: 12 months]
Correlation of myocardial damage to SUV [Срок оценки: 12 months]
Correlation of SUV with the clincial course [Срок оценки: 12 months]

Критерии участия

Критерии включения

patients with acute myocardial infarction (STEMI) who were treated with immediate catheterization
stable clinical course
male/female, above 18 years old