Lower Silesia Cardiogenic Shock Initiative
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Structured treatment of cardiogenic shock patients.
- Кому может быть актуально
- Состояния в реестре: Cardiogenic Shock. Базовые параметры: 18 лет — 60 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Польша
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Coordinated Treatment of Cardiogenic Shock Patients in Lower Silesia, Poland
Обзор
LSCSI is a Hub\&Spoke project with the main aim to improve the outcome of patients with cardiogenic shock in Lower Silesia region, Poland. It consists of one "hub" which is Wroclaw University Hospital and eleven "spokes" which are eleven cardiology departments situated in Lower Silesian Voivodeship. The consortium have unified protocol defining which cardiogenic shock patient and when should be transferred to the "hub" for enhanced treatment options including durable mechanical circulatory support or heart transplant. The "hub" have 7/24 Shock Team on-site supplied with a protocol how to proceed with "spoke" transferred patients including decision making on which mechanical circulatory support implant with subsequent de-escalation or escalation pathway.
Подробное описание
LSCSI is a Hub\&Spoke project with the main aim to improve the outcome of patients with cardiogenic shock in Lower Silesia region, Poland. It consists of one "hub" which is Wroclaw University Hospital and eleven "spokes" which are eleven cardiology departments situated in Lower Silesian Voivodeship. The consortium have unified protocol defining which cardiogenic shock patient and when should be transferred to the "hub" for enhanced treatment options including durable mechanical circulatory support or heart transplant.
Shared cardiogenic shock definition:
1. Systolic blood pressure \< 90 mmHg for \> 30 minutes or need for vasopressors use to maintain systolic blood pressure \> 90 mmHg 2. Lactate level \> 2.0 mmol/L 3. Pulmonary capillary wedge pressure or left ventricle end diastolic pressure \> 15 mmHg (excluding pulmonary embolism) 4. Cardiac Index ≤ 2.2 l/min/m2 5. Diuresis \< 30 ml/h 6. Clinical signs of peripheral hypoperfusion
Data required by "hub" from "spoke"
1. Echocardiography with data on left and right ventricle function 2. Current aortic and mixed venous blood gases 3. Pulmonary artery catheter measurements including calculation of cardiac power, pulmonary artery pulsatile index, cardiac output, cardiac index, pulmonary artery wedge pressure, pulmonary vascular resistance, systemic vascular resistance (excluding pulmonary embolism) 4. Peripheral blood tests including liver and kidney function, morphology, troponin, natriuretic peptides 5. Currently used and possible for use vascular accesses 6. For pulmonary embolism: computed tomography of pulmonary arteries
Upon telephone contact "hub" shock team decides on patients transfer or further treatment in "spoke" facility. When decision on transfer is taken shock team members gather at emergency room when patient arrives and decides on treatment options according to shock team protocol. As a "hub" Wroclaw University Hospital provides mechanical circulatory support (Intra-aortic balloon pump, Impella CP (Cardiac Power), Impella 5.0, Impella RP (Right Pump), ECMO (ExtraCorporeal Membrane Oxygenation), Levitronix, HeartMate3) together with heart transplant program as a regional reference center for advanced heart failure patients. Additionally for acute pulmonary embolism complicated by shock "hub" provides peripheral or local thrombolysis and in case of contraindication for thrombolysis - transcatheter thrombectomy or surgical embolectomy.
Вмешательства
- Процедура Structured treatment of cardiogenic shock patients
Creation of hub\&spoke structure which covers all Lower Silesian Voivodeship (Poland) for treatment of cardiogenic shock patients. Based on shared protocol patients are reported to "hub" by "spoke" and decision is made as for patient transfer or further treatment in the "spoke" facility. If decision on transfer is made, patient is further treated according to "hub" on site shock team protocol
Первичные конечные точки
- 30-days all-cause mortality [Срок оценки: 30 days]
Вторичные конечные точки (1)
- 12-months mortality [Срок оценки: 12 months]
Критерии участия
Критерии включения
- Fulfilled definition of cardiogenic shock
- Age 18 - 60 years
- Shock duration below 24 hours
Критерии исключения
- History of cardiac arrest with anoxemic brain injury
- Irreversible multiorgan failure
- End stage of chronic diseases other than heart failure
- Neoplastic disease
- Lack of vascular access
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Польша · 1 центр
- Institute of Heart Disease of Wroclaw Medical University — Wroclaw
Публикации
- Krupka D, Chelmonski A, Karska K, Mazur K, Cicirko K, Drewniowska J, Florek K, Grunwald K, Milewski M, Nnoli M, Ptak J, Blaziak M, Balcer B, Zymlinski R, Gozdzik W, Barteczko-Grajek B, Bochenek M, Przybylski R, Zakliczynski M, Kuliczkowski W, Sokolski M. Clinical characteristics of patients with cardiogenic shock after out-of-hospital cardiac arrest (OHCA) compared to patients with cardiogenic sho PMID 42047026
Идентификаторы
NCT: NCT05465200 · WMU012021