Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI

Обзор

Standard Magnetic Resonance Imaging (MRI) is based on the excitation of hydrogen nuclei that are presents in water molecules, which abundance in human body allows for obtention of superior contrast. However, assessing the presence of other molecules than water in tissues is also of great clinical interest to probe metabolites related to physiological body function and pathological conditions. Chemical exchange saturation transfer (CEST) allow to overcome some limitations of proton magnetic resonance spectroscopy (1H-MRS) by exploiting chemical properties of the targeted molecule through a continuous process of re-saturation and exchange, and thus detecting it with increased sensitivity, from two orders of magnitude. Moreover, CEST technique is based on imaging sequences and can therefore benefit from well-known fast acquisition strategies, as well as improved spatial resolution.

Подробное описание

For this study the investigators propose to include an additional CEST sequence in standard PET/MRI exam in order to obtain a cartography with biochemical informations from tissues in patients with glioma or brain metastases.

Вмешательства

• Другое Additional CEST sequences during PET/MRI exam
  CE-Marked Advanced Technology Software Modules (ATSM) for Magnetic Resonance Imaging from General Electric Healthcare

Первичные конечные точки

• Obtention, from a set of brain PET-MRI images, of an intratissular pH mapping in patients with glioma or brain metastases [Срок оценки: through study completion, up to 14 years]
• Obtention, from a set of brain PET-MRI images, of an intratissular pH mapping in patients with glioma or brain metastases [Срок оценки: through study completion, up to 14 years]

Вторичные конечные точки (4)

• Correlate intratissular pH mapping and location of recurrence [Срок оценки: through study follow-up, up to 10 years]
• Correlate average pH of the tumor and histopathology [Срок оценки: through study follow-up, up to 10 years]
• Correlate average pH of the tumor and Disease-Free Survival (DFS) [Срок оценки: through study follow-up, up to 10 years]
• Correlate average pH of the tumor and Overall survival (OS) [Срок оценки: through study follow-up, up to 10 years]

Критерии участия

Критерии включения

Patients admitted to the Nuclear Medicine and Molecular Imaging department of ICANS (Institut de cancérologie strasbourg Europe) for a PET/MRI exam dedicated to:

• Preoperative evaluation of a cerebral expansion lesion
• Evaluation of glioma recurrences
• Evaluation of brain metastases
• Evaluation of recurrence of metastases

Критерии исключения

• Contraindication to the realization of an MRI
• Minor or patients placed under guardianship or supervision
• Patients deprived of liberty
• Patients placed under judicial protection
• Patients that are not able to express their consent
• Pregnant and breastfeeding women

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Другое

Центры проведения

Франция · 1 центр

• France Institut de cancérologie Strasbourg Europe — Strasbourg

Идентификаторы

NCT: NCT05464992 · 2022-005 · 2022-A00910-43

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗