Filter Lifespan in Continuous Renal Replacement Therapy
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Critically ill patients with continuous renal replacement therapy.
- Кому может быть актуально
- Состояния в реестре: Critically Ill, Continuous Renal Replacement Therapy, Infections. Базовые параметры: от 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Австрия, Бразилия, Германия
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
The Effect of Filter Lifespan in Continuous Renal Replacement Therapy on the Rate of New Infections in Critically Ill Patients: a Prospective, Multicenter, Observational Trial
Обзор
The only supportive therapy for patients with AKI is renal replacement therapy (RRT). In the ICU setting, continuous RRT (CRRT) is mostly favored. In a post-hoc analysis of the RICH trial (regional citrate versus systemic heparin anticoagulation for CRRT in critically ill patient with AKI), it was shown that the filter life span is associated with an increased rate of new infection and that the type of anticoagulants did not directly affect infection rate. The mechanisms of this infection rate is unknown.
Подробное описание
Approximately every second patient in the ICU suffers from acute kidney injury (AKI) which complicates the clinical course of these patients. Continuous renal replacement therapy (CRRT) has become the most widely used form of renal support in critically ill patients as it allows continuous, controlled removal of fluids and is hemodynamically better tolerated compared to intermittent dialysis. The requirement for intravascular access and artificial circuits may increase the risk of infection. However, there are no studies analyzing the incidence and characteristics of infections in critically ill patients with CRRT or the implications for outcome. Therefore, this observational trial investigates the factors that influences new onset infection in critically ill patients with CRRT.
Вмешательства
- Процедура Critically ill patients with continuous renal replacement therapy
Due to the observational design of the study, no study-specific interventions are performed. The treatment of the patients is completely guided by the responsible ICU physicians.
Первичные конечные точки
- Number of new infections since start of dialysis [Срок оценки: From start of dialysis until day 28]
Вторичные конечные точки (12)
- Number of new blood stream infections [Срок оценки: From start of dialysis until day 28]
- Number of new pneumonia [Срок оценки: From start of dialysis until day 28]
- Number of new urinary tract infection [Срок оценки: From start of dialysis until day 28]
- Number of new catheter blood stream infection [Срок оценки: From start of dialysis until day 28]
- Number of new other infections [Срок оценки: From start of dialysis until day 28]
- Filter live span [Срок оценки: From start of dialysis until day 28 or end of CRRT, whatever occurs first]
- Number of bacterial contamination of t he CRRT circuit proven by culture [Срок оценки: From start of dialysis until day 28 or end of CRRT, whatever occurs first]
- Down-time of CRRT in hours [Срок оценки: From start of dialysis until day 28 or end of CRRT, whatever occurs first]
- Days on renal replacement therapy [Срок оценки: From start of dialysis until day 28]
- Duration of mechanical ventilation in hours [Срок оценки: From start of dialysis until day 28]
- Number of bleeding complications [Срок оценки: From start of dialysis until day 28]
- Recovery of kidney function [Срок оценки: At day 28 after start of dialysis]
Критерии участия
Критерии включения
- Adult patients (age ≥18 years)
- Critically ill patients with dialysis-dependent AKI
- Continuous renal replacement therapy (CRRT)
- Written informed consent
Критерии исключения
- Chronic kidney disease with estimated glomerular filtration rate (eGFR)<30ml/min/1.73m2
- Chronic dialysis dependency
- Kidney transplant
- (Glomerulo-)nephritis, interstitial nephritis, vasculitis
- Patients on immunosuppression
- Patients with chronic inflammatory diseases (e.g. arthritis, HIV, chronic hepatitis)
- Persons with any kind of dependency on the investigator or employed by the sponsor or investigator
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Германия · 3 центра
- Universitätsklinikum Erlangen-Nürnberg, Abteilung für Nephrologie und Hypertensiologie — Erlangen
- Kliniken Maria Hilf, Klinik für Anästhesiologie und Operative Intensivmedizin — Mönchengladbach
- University Hospital Muenster — Münster
Австрия · 1 центр
- Univ.-Klinik Innsbruck — Innsbruck
Бразилия · 1 центр
- Universidade de São Paulo — São Paulo
Идентификаторы
NCT: NCT05450185 · 10-AnIt-21