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Идёт набор NCT05344001

Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

— Наблюдательное Aging Athletic Injuries Physical Inactivity Knee Injuries and Disorders

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально
Состояния в реестре: Aging, Athletic Injuries, Physical Inactivity, Knee Injuries and Disorders. Базовые параметры: 18 лет — 64 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
США
Следующий шаг
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Обзор

Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.

Подробное описание

The overarching hypothesis is that former athletes, especially those with a prior injury, will have poorer function and health in midlife and that current and former athletes will engage in greater overall and longer bouts of sedentary behavior compared to non-athletes.

Aim 1 will compare function, strength, and cardiometabolic indicators among former athletes with and without prior knee injury and non-athlete controls in midlife (age 40-64). Hypothesis 1 is that former athletes with a prior injury will have the poorest function, muscle strength, and cardiometabolic indicators.

Aim 2 will compare sedentary behavior and physical activity patterns in current (age 18-25) and midlife former athletes to non-athlete controls. Hypothesis 2.1 is that current athletes will have greater sedentary behavior, longer sedentary behavior bouts, and higher levels of moderate-to-vigorous physical activity compared to non-athlete controls. Hypothesis 2.2 is that former athletes in midlife will have greater sedentary behavior, longer sedentary behavior bouts, and lower physical activity levels compared to non-athlete controls.

An exploratory aim will evaluate longitudinally the trajectory of physical activity patterns, cardiometabolic indicators, function, and strength annually in each cohort, comparing how these variables change over time in each subgroup.

Первичные конечные точки

  • 30-Second Chair Stand Test (primary outcome for Aim 1) [Срок оценки: Baseline]
  • Sedentary Behavior (primary outcome for Aim 2) [Срок оценки: Baseline]
Вторичные конечные точки (12)
  • Strength [Срок оценки: Baseline]
  • Body Composition [Срок оценки: Baseline]
  • Step Counts [Срок оценки: Baseline]
  • Cardiovascular Disease Risk [Срок оценки: Baseline]
  • 6-Minute Walk Test [Срок оценки: Baseline]
  • Stair Climb Test [Срок оценки: Baseline]
  • Sedentary Behavior (follow-up) [Срок оценки: Follow-up (an average of 1 year post-baseline)]
  • 30-Second Chair Stand Test (follow-up) [Срок оценки: Follow-up (an average of 1 year post-baseline)]
  • Strength (follow-up) [Срок оценки: Follow-up (an average of 1 year post-baseline)]
  • Body Composition (follow-up) [Срок оценки: Follow-up (an average of 1 year post-baseline)]
  • Step Counts (Follow-up) [Срок оценки: Follow-up (an average of 1 year post-baseline)]
  • 6-Minute Walk Test (follow-up) [Срок оценки: Follow-up (an average of 1 year post-baseline)]

Критерии участия

Please see cohorts for specific inclusion/exclusion criteria

Критерии включения

  • Age 18-25 years OR age 40-64 years
  • Current or former collegiate varsity athlete OR non-athlete control

Критерии исключения

  • Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function
  • Pregnancy
  • Lower extremity joint replacement (e.g., hip or knee replacement)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

США · 1 центр
  • Marquette University — Milwaukee

Идентификаторы

NCT: NCT05344001 · 3967 · DP5OD031833

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗