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Идёт набор NCT05278520

Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis

— Наблюдательное Osteoarthritis, Hip Rheumatoid Arthritis

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Total hip arthroplasty.
Кому может быть актуально
Состояния в реестре: Osteoarthritis, Hip, Rheumatoid Arthritis. Базовые параметры: 18 лет — 74 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Финляндия
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Studies on the Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis

Обзор

The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.

Подробное описание

The specific objectives of this project are:

1. Using the latest single-cell RNA sequencing (scRNAseq) techniques the investigators aim to A) characterize what kind of cell populations are found in different synovial tissues and blood derived samples of OA patients, B) determine how the cell composition differs between arthritic and corresponding non-arthritic tissues, C) map the transcriptional and regulatory landscape of the cells mentioned in A and B focusing on the inflammatory responses, D) determine what are the key molecular pathways activated in OA. 2. To determine if some of the blood-derived immune cell populations or their products could be used as biomarkers for OA. 3. To map the whole transcriptome and proteome of OA and non-arthritic control tissue while keeping the morphological context with spatial omics technologies. 4. Further differentiation and identification of OA endotypes utilizing the single-cell and spatial omics data.

The project includes a Rheumatoid sub-study where the main objective is to compare arthritic tissue and peripheral blood constituents between OA and rheumatoid arthritis patients to explore the differences in the disease mechanisms.

Вмешательства

  • Процедура Total hip arthroplasty
    Hip joint replacement surgery. Elective for RA and OA cases.

Первичные конечные точки

  • Characterization of cell populations in OA [Срок оценки: Starting during the first quarter of 2025, ending by the last quarter of 2026.]
  • Comparison of cell populations between OA cases and controls [Срок оценки: Starting during the first quarter of 2025, ending by the last quarter of 2026.]
  • Cellular landscape in OA [Срок оценки: Starting during the last quarter of 2024, ending by the last quarter of 2026.]
  • Key molecular pathways of OA [Срок оценки: Starting during the last quarter of 2025, ending by the last quarter of 2027.]
  • Comparison of disease mechanisms between RA and OA [Срок оценки: Starting during the last quarter of 2024, ending by the last quarter of 2028.]
Вторичные конечные точки (2)
  • Biomarkers for OA [Срок оценки: Starting during the second half of 2026, ending by the last quarter of 2028.]
  • OA endotypes [Срок оценки: Starting during the first half of 2025, ending by the second half of 2027.]

Критерии участия

Inclusion Criteria for the main (OA) study:

Cases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.

Controls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.

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Inclusion Criteria for the Rheumatoid sub-study:

Adult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.

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Критерии исключения

  • The body mass index must be below 35
  • Age < 18 or > 74
  • The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.

For the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Случай-контроль

Центры проведения

Финляндия · 4 центра
  • PET-centre, University of Turku — Turku
  • Turku Bioscience, University of Turku — Turku
  • Turku University Hospital — Turku
  • Helsinki University Hospital — Espoo

Публикации

  • Rydgren E, Kotilainen SK, Piipponen M, Lönnberg T, Mikkola L. COMPARISON OF TWO HIGH-RESOLUTION SPATIAL TRANSCRIPTOMICS TECHNOLOGIES TO STUDY SYNOVIAL IMMUNE INFILTRATION IN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS Osteoarthritis and Cartilage, Volume 33, Issue 6, 2025, page 816. https://doi.org/10.1016/j.joca.2025.03.079

Идентификаторы

NCT: NCT05278520 · 2022OASEQ

Первоисточники (государственные реестры)

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