Metabolic and Functional Consequences of Aging in Health and Disease

Обзор

Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. Current knowledge of the aging experience and the trajectories of physical and cognitive decline across various age groups are not well-understood, yet crucial to prevent spending added years in disease. Hence, the study objective is to develop the metabolic profile associated with aging-related disorders measured as the incidence of impaired functional capacity, cognitive function, and/or well-being.

Подробное описание

Our lab developed a pulse method combining multiple stable tracers to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, we may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with a special interest in the metabolism of amino acids as they have been associated with aging-related disorders. Studies on the effect of aging on metabolism might serve as potential therapeutic targets.

Вмешательства

• Другое Stable tracer infusion in a postabsorptive state
  Multiple stable-labeled tracers of amino acids, ketoacids, glycerol, short-chain fatty acids

Первичные конечные точки

• Age-related changes in whole-body protein and amino acid metabolism [Срок оценки: 2 hours]

Вторичные конечные точки (12)

• Age-related changes in whole-body glucose metabolism [Срок оценки: 2 hours]
• Age-related changes in whole-body fat metabolism [Срок оценки: 2 hours]
• Age-related changes in depression as measured by the Hospital Anxiety and Depression Scale (HADS) and Geriatric Depression Scale (if applicable) [Срок оценки: baseline visit]
• Age-related changes in anxiety as measured by the Hospital Anxiety and Depression Scale (HADS) [Срок оценки: baseline visit]
• Age-related changes in mood as measured by the Profile of Mood State (POMS) [Срок оценки: baseline visit]
• Age-related changes in health status [Срок оценки: baseline visit]
• Age-related changes in physical activity [Срок оценки: baseline visit]
• Age-related changes in sleep quality [Срок оценки: baseline visit]
• Age-related changes in nutritional status [Срок оценки: baseline visit]
• Age-related changes in attention and executive functions as measured by Trail Making Test (TMT) [Срок оценки: baseline visit]
• Age-related changes in overall cognitive abilities as measured by Montreal Cognitive Assessment (MoCA) [Срок оценки: baseline visit]
• Age-related changes in exercise capacity [Срок оценки: baseline visit]

Критерии участия

Критерии включения

• Stable body-weight (± 5%) for the past 3 months
• Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations.
• Ability to walk, sit down and stand up independently or with walking mobility aids
• Ability to lie in a supine or elevated position for up to 3 hours
• Willingness and ability to comply with the protocol

Критерии исключения

• Insulin dependent diabetes mellitus
• Established diagnosis of malignancy
• History of untreated metabolic diseases including hepatic or renal disorder
• Presence of acute illness or metabolically unstable chronic illness
• Presence of fever within the last 3 days
• Use of short course of oral corticosteroids within 4 weeks preceding study day
• Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
• (Possible) pregnancy
• Already enrolled in another clinical trial and that clinical trial interferes with participating in this study

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

США · 1 центр

• Human Clinical Research Building — College Station

Публикации

• Huttl VN, Deutz N, Wierzchowska-McNew RA, Ruebush LE, Engelen M. Whole-body and intracellular arginine metabolism in hypertension: role of disease severity and sex. Am J Hypertens. 2026 May 18:hpag047. doi: 10.1093/ajh/hpag047. Online ahead of print. PMID 42149813

Идентификаторы

NCT: NCT05240885 · 2021-1413 · 82-Aging

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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