Spatiotemporal Dynamics of the Human Emotion Network

Обзор

The overall goal of this study is to elucidate how emotion network dynamics relate to the behavioral, autonomic, and experiential changes that accompany emotions and to investigate how emotion network dysfunction relates to affective symptoms. Affective symptoms are a common feature of neuropsychiatric disorders that reflect dysfunction in a distributed brain network that supports emotion. How aberrant functioning in a single emotion network underlies a wide range of affective symptoms, such as depression and anxiety, is not well understood. Anchored by the anterior cingulate cortex and ventral anterior insula, the emotion network responds to numerous affective stimuli. The recording of neural activity directly from the cortical surface from individuals is a promising approach since intracranial electroencephalography (iEEG) can provide direct estimates of neuronal populations to map the spatiotemporal dynamics of the emotion network at a millisecond level resolution. This study will exam how activity within emotion network hubs changes during emotions and how emotion network properties make some individuals more vulnerable to affective symptoms than others. A multidisciplinary approach is critical for understanding the dynamic brain network to advance neuroanatomical models of emotions and for guiding the development of novel treatments for affective symptoms.

Подробное описание

Intracranial EEG (iEEG) recordings make it possible to obtain direct measures of emotion network dynamics not possible with other methods. This study proposes to conduct a multimodal assessment of emotions in patients with epilepsy who are undergoing surgery for seizure localization. Electrodes will be placed in sites based on the clinical needs of each patient and will include sites within and outside of the emotion network. The research study team will examine measures of behavior, autonomic nervous system (ANS) activity, and subjective experience to continuous iEEG recordings to determine how emotion network dynamics relate to emotions and affective symptoms. Affective symptoms are common in epilepsy, with nearly one third of patients meeting diagnostic criteria for a severe anxiety or depressive disorder during their lifetimes. This clinical population offers a unique opportunity to obtain direct recordings of emotion network activity with concurrent measures of emotion physiology and behavior. The aims of this study seeks to determine how emotion network activity relates to naturalistic affective behaviors (Aim 1), whether we can uncover the unique neural signatures of discrete emotions and examine their relation to task-based measures of emotional reactivity (Aim 2), and whether electrical stimulation of emotion network changes network activity and alters emotions, mood, and anxiety (Aim 3). Together, these aims will help to uncover the neural mechanisms that produce, sense, and regulate emotions. These results should heavily impact the current understanding of the neurobiological systems that underlie affective symptoms and, therefore, will have significant implications for identifying biomarkers of system dysfunction to guide development of new treatments.

Вмешательства

• Поведенческое Viewing visual stimuli and electrical stimulation of the brain
  View emotionally evocative videos and undergo stimulation of brain regions involved in emotion. In a 20-minute block (5 total blocks), eighteen 30-second movie clips will be used to elicit different categories of emotions (sadness, fear, disgust, awe, affection, and amusement). Additionally, each hub of the emotion network will be stimulated to identify areas that generate similar emotional states as those elicited by the videos. Each stimulation trial consists of 3 minutes of 1-3 mA, 50 Hz, 100

Первичные конечные точки

• Mean Change from Baseline in Heart Rate [Срок оценки: During inpatient hospitalization, approximately 4-14 days]
• Mean Change from Baseline in Respiratory Rate [Срок оценки: During inpatient hospitalization, approximately 4-14 days]
• Mean change from Baseline in Electrodermal Activity [Срок оценки: During inpatient hospitalization, approximately 4-14 days]
• Mean Facial Expression Activity [Срок оценки: During inpatient hospitalization, approximately 4-14 days]
• Mean Change from Baseline in Neural Activity within the Emotion Network [Срок оценки: During inpatient hospitalization, approximately 4-14 days]

Вторичные конечные точки (1)

• Mean Subjective Experience [Срок оценки: During inpatient hospitalization, approximately 4-14 days]

Критерии участия

Критерии включения

• Participants with epilepsy at UCSF undergoing surgical electrode implantation for seizure localization and
• Participants with electrodes implanted in at least two regions of interest who are willing and able to cooperate with study tasks.

Критерии исключения

• Participants who lack capacity or decline to provide informed consent,
• Participants who have significant cerebral lesions or
• Participants with cognitive deficits that preclude reliable completion of study tasks.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

США · 1 центр

• University of California, San Francisco — San Francisco

Идентификаторы

NCT: NCT05152992 · R01MH122431 · R01MH122431

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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