Health Benefits of Whole-body Vibration

Официальное название

Pilot Investigation on the Health Benefits of Sub Acute (12 Week) Whole-body Vibration Training

Обзор

The overall goals of this pilot investigation are to determine 1) the feasibility of conducting home based WBV studies, and 2) to determine if sub-acute home based WBV can improve a) exercise capacity, b) conduit- and micro- vascular function, and c) skeletal muscle function.

Подробное описание

Cardiovascular disease (CVD) is the leading cause of death in the world and many comorbid conditions (i.e. diabetes, obesity) can affect overall CVD risk. There is increasing interest into the role that skeletal muscle health plays in mediating CVD risk, particularly in metabolic disease states (ie. obesity and diabetes). Whole body vibration (WBV) has emerged as an exercise mimetic that may be more tolerable than traditional modes of exercise, such as treadmill walking/running or cycling. Similar to traditional exercise modalities, WBV can elicit beneficial metabolic effects. In fact, a single bout of WBV increases circulating concentrations of IL-6, which correspond with the normalization of glucose and insulin in obese individuals. The proposed pilot investigation will provide the foundation to begin understanding the molecular and physiological mechanisms of how sub-acute WBV can improve overall CVD risk. We hypothesize that home based WBV will decrease CVD risk by improving skeletal muscle and vascular function via a decrease in systemic inflammation.

Вмешательства

• Другое Sub Acute Whole Body Vibration Training
  Participants will be given a personal vibration plate to take home with them for training which will last for 12 weeks. For the first four weeks, participants will be asked to complete 10 minutes of WBV per day (1 minute on and up to 1 minute of rest), at least 3-4 days per week. At least 24 hours will be recommended in between sessions during weeks 1-4. Beginning at week 5, participants will be asked to increase WBV time to up to 14 minutes and/or reduce the duration of rest. Beginning at week

Первичные конечные точки

• Change in VO2 Peak [Срок оценки: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
• Change in Flow-Mediated Dilation (FMD) [Срок оценки: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
• Change in Skeletal Muscle Mitochondrial Function [Срок оценки: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
• Change in Pulse Wave Velocity (PWV) [Срок оценки: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
• Change in Post Occlusive Reactive Hyperemia (PORH) [Срок оценки: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
• Change in IL-6 [Срок оценки: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]

Критерии участия

Критерии включения

• Men and women (> 18 yrs old)
• All races

Критерии исключения

• <18 years old
• Clinical diagnosis of hepatic, cardiovascular, or renal disease
• Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
• Pregnancy
• Direct vasoactive medications (i.e. nitrates)

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

США · 1 центр

• Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Ph — Augusta

Идентификаторы

NCT: NCT05097885 · 1818010

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗