Progression of Atrial Fibrillation in the Young
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Atrial Fibrillation. Базовые параметры: 18 лет — 50 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Швеция
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Не всё понятно в терминах? Прочитайте наш гид для пациентов →
Обзор
The purpose of this study is to investigate the presence and magnitude of structural changes of the heart and their long-term development in young patients with atrial Fibrillation (AF), studied by echocardiographic measurements and plasma biomarkers and their association to AF burden, studied using long-term ECG
Подробное описание
100 patients with symptomatic Atrial Fibrillation diagnosis are included. Diagnosis is set either at the index visit or within 12 months before inclusion. . The follow up period is 5 years. Patients presenting with AF in connection with acute infection, acute cardiac ischemia, surgery or thyroid disease are excluded. Further, AF patients with cardiomyopathies, known genetic diseases and congenital cardiac abnormalities are also excluded.
At inclusion patients undergo an in-depth interview regarding comorbidities, medication, previous treatments related to the AF diagnosis. In addition, baseline data for weight and height are collected.
In connection to inclusion the patients are asked leave venous bloodwork (Na, K, Creatinine, plasma Glucose and NTproB-Type Natriuretic Peptide). An echocardiographic exam is performed according to a prespecified protocol with special emphasis on the left atrial function and anatomy. This is followed by a continuous ECG recording for 14 days using BioTel ePatch. The ECG patch is later returned to a core facility by mail.
The patients´ are followed for five years and are asked to leave bloodwork and perform a 14-day ECG recording yearly. After these exams, a follow up phone call is placed to the patient aimed at documenting clinical progress related to symptoms, treatment and interventions. After 5 years follow up patients undergo a follow up echocardiographic exam in addition to yearly bloodwork and ECG recording. The patients´ clinical symptoms are treated at the clinician´s discretion according to current guidelines.
Первичные конечные точки
- Development of atrial fibrillation burden [Срок оценки: change from baseline at 5 years]
Вторичные конечные точки (8)
- Development of humoral measures of hemodynamic status [Срок оценки: Change from baseline at 5 years]
- Development of atrial electrocardiographic status [Срок оценки: Change from baseline at 5 years]
- Development of supraventricular ectopies [Срок оценки: Change from baseline at 5 years]
- Development of atrial fibrillation incident [Срок оценки: Change from baseline at 5 years]
- Development of echocardiographic status [Срок оценки: Change from baseline at 5 years]
- Development of left atrial systolic function by echocardiography [Срок оценки: Change from baseline at 5 years]
- Development of left atrial volume by echocardiography [Срок оценки: Change from baseline at 5 years]
- Development of left ventricular systolic function by echocardiographic [Срок оценки: Change from baseline at 5 years]
Критерии участия
Критерии включения
- Atrial fibrillation
- Diagnosis of atrial fibrillation within one year of inclusion
Критерии исключения
- Duration of atrial fibrillation over one year.
- Acute stressor for atrial fibrillation such as: acute ischemic heart disease or infection
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Швеция · 1 центр
- Danderyd Hospital — Stockholm
Идентификаторы
NCT: NCT05080712 · 2021-00992