Efficacy of Patient Management for Lymphoma Diagnosed at Nimes University Hospital From 1999 to 2018. DVR-Lym-Nim
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Lymphoma, Malignant. Базовые параметры: от 15 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Франция
- Следующий шаг
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Официальное название
Evaluation of the Efficacy of Management of Patients With Lymphomas Diagnosed at Nimes University Hospital Over 20 Years (1999-2018) Under Real-life Circumstances
Обзор
Observation of a cohort of 400 patients with different types of lymphomas.
Подробное описание
A database on 400 patients diagnosed with lymphomas was built up over 20 years at Nîmes University Hospital. Biopsies were made on these tumours and all the samples were frozen.
Considering the heterogeneous nature of lymphomas, randomized clinical trials based on very precise criteria for the inclusion or non-inclusion of patients are the gold standard for studying the various sub-types of lymphomas by concentrating on homogeneous populations for which a limited number of parameters are analyzed simultaneously. However, due to the complexity of their medical situation, many patients may be excluded form these trials, thus making it difficult to obtain reliable results.
The analysis of a non-selected cohort has two main advantages: (1) to better understand the diversity of patients with lymphomas for which the recommendations are constantly evolving and (2) to analyze how, exactly, these are managed by integrating points which are currently poorly evaluated such as comorbidities and accessibility to treatment.
The aim of the study is to describe how these patients are managed and to demonstrate that not all patients are able to benefit from the official management recommendations applicable to their pathology.
Первичные конечные точки
- Overall survival rate among patients with Hodgkin Lymphomas [Срок оценки: 2 years after inclusion]
- Overall survival rate among patients with Mantle-cell Lymphomas [Срок оценки: 2 years after inclusion]
- Overall survival rate among patients with Primitive Cerebral Lymphomas [Срок оценки: 2 years after inclusion]
- Overall survival rate among patients with Follicular Lymphomas [Срок оценки: 2 years after inclusion]
- Overall survival rate among patients with Marginal Zone Lymphomas [Срок оценки: 2 years after inclusion]
- Overall survival rate among patients with Waldenström's Disease [Срок оценки: 2 years after inclusion]
Вторичные конечные точки (12)
- Differences between management of patients with Hodgkin Lymphomas actually observed and data described in the literature. [Срок оценки: 2 years after inclusion]
- Differences between management of patients with Mantle-cell Lymphomas and data described in the literature. [Срок оценки: 2 years after inclusion]
- Differences between management of patients with Primitive Cerebral Lymphomas and data described in the literature. [Срок оценки: 2 years after inclusion]
- Differences between management of patients with Follicular Lymphomas and data described in the literature. [Срок оценки: 2 years after inclusion]
- Differences between management of patients with Marginal Zone Lymphomas and data described in the literature. [Срок оценки: 2 years after inclusion]
- Differences between management of patients with Waldenström's Disease and data described in the literature. [Срок оценки: 2 years after inclusion]
- Reasons for differences between management of patients with Hodgkin Lymphomas actually observed and data described in the literature. [Срок оценки: 2 years after inclusion]
- Reasons for differences between management of patients with Mantle-cell Lymphomas actually observed and data described in the literature. [Срок оценки: 2 years after inclusion]
- Reasons for differences between management of patients with Primitive Cerebral Lymphomas actually observed and data described in the literature. [Срок оценки: 2 years after inclusion]
- Reasons for differences between management of patients with Follicular Lymphomas actually observed and data described in the literature. [Срок оценки: 2 years after inclusion]
- Reasons for differences between management of patients with Marginal Zone Lymphomas actually observed and data described in the literature. [Срок оценки: 2 years after inclusion]
- Reasons for differences between management of patients with Waldenström's Disease actually observed and data described in the literature. [Срок оценки: 2 years after inclusion]
Критерии участия
Критерии включения
- Patients over the age of 15 years and 3 months, diagnosed with lymphoma at Nîmes University Hospital as from 1999 onwards and for whom diagnostic tumor material is available.
Критерии исключения
- Patients aged 18 or over who have expressed their desire not to take part in the study.
- Patients under the age of 18 whose legal representatives have expressed their desire for the child not to take part in the study.
- Patients under legal guardianship.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Франция · 1 центр
- CHU Nimes — Nîmes
Идентификаторы
NCT: NCT04947618 · NIMAO/2019-01/EJ-01