Comparative Study of Gender Identity Disorder Versus Control
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Psychiatric evaluations.
- Кому может быть актуально
- Состояния в реестре: Gender Dysphoria, Adult. Базовые параметры: 18 лет — 60 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Франция
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Comparative Study of Gender Dysphoria Phenomenology and Neurophysiology: Clinical and Experimental Exploration of Gender Identity Disorder
Обзор
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.
Подробное описание
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity. Gender dysphoria is accompanied by the often overwhelming need for a hormonal or even hormone-surgical transition. Gender dysphoria is very often characterized by fluctuating mood sadness, irritability, obsessionality. An improvement in the quality of life after medical treatment (hormone therapy) and gender reassignment surgery has been described in the literature. Morphological similarities have been found between the brains of women and the brains of so-called transgender women, as well as between the brains of transgender men and men. These morphological data are only very fragmentary and have not been supported by neuro-functional data. Self-awareness, which refers to the awareness that an individual has of his body, his image and his own identity, is partly underpinned, at the brain level, by the activation of the Default Mode Network (DMN) at rest, in non-pathological conditions. The conflict between the internal perception of the own body and its objective representation could result in a change in brain connectivity within the DMN, due in particular to changes in the activation of the temporo parietal junction.
Вмешательства
- Другое Psychiatric evaluations
At different time points, several psychiatric evaluations will be performed on patients and volunteers for study purposes
Первичные конечные точки
- Contribution of temporal parameters of microstates C, D, E and F [Срок оценки: Week 1 to Week 24]
- Duration of temporal parameters of microstates C, D, E and F [Срок оценки: Week 1 to Week 24]
- Mean-Global Field Power temporal parameters of microstates C, D, E and F [Срок оценки: Week 1 to Week 24]
- Occurrence of temporal parameters of microstates C, D, E and F [Срок оценки: Week 1 to Week 24]
- Cortical voxel activity from source reconstruction analysis, using electroencephalogram during Double Mirror Test (D.M.T). [Срок оценки: Week 1 to Week 24]
Критерии участия
Критерии включения
- Patients with gender dysphoria
- Without psychotropic
- Without hormono-therapy
- Without sexual surgery assignation
Критерии исключения
- Any depression
- Any addiction
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Случай-контроль
Центры проведения
Франция · 1 центр
- Centre Hospitalier Henri Laborit — Poitiers
Идентификаторы
NCT: NCT04935164 · 2020-A03407-32