Effects of PFC tDCS on Cognitive Control, Attention Lapses and Coordinated Neural Activity in the Theta and Alpha Bands

Обзор

The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language comprehension, cognitive control, and related attention and memory processes). Behavioral and electrophysiological (EEG) measures will be used to assess cognitive performance. Our overarching hypothesis is that stimulating prefrontal circuits with tDCS can improve cognitive control performance, and ultimately performance on a range of cognitive tasks, as compared to stimulating a different cortical region (occipital cortex) or using sham stimulation. This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.

Вмешательства

• Устройство Transcranial Direct Current Stimulation
  In tDCS, saline-soaked electrodes are temporary affixed to the scalp and connected to a battery-powered current generator. A weak (2 mA) constant current is then briefly applied (\~20 minutes) to stimulate the targeted brain area. The targeted brain area is determined by the Study Arm.

Первичные конечные точки

• Behavioral Cognitive Control Measures on the Stroop Task [Срок оценки: Through study completion, an average of 1 month]
• EEG Cognitive Control Measures on the Stroop Task [Срок оценки: Through study completion, an average of 1 month]
• Behavioral Attention Lapse Measures on the Stroop Task [Срок оценки: Through study completion, an average of 1 month]
• EEG Attention Lapse Measures on the Stroop Task EEG Attention Lapse Measures on the Stroop Task [Срок оценки: Through study completion, an average of 1 month]
• Behavioral Cognitive Control Measures on the Change Detection Task Behavioral Cognitive Control Measures on the Change Detection Task [Срок оценки: Through study completion, an average of 1 month]
• EEG Cognitive Control Measures on the Change Detection Task [Срок оценки: Through study completion, an average of 1 month]
• Behavioral Attention Lapse Measures on the Change Detection Task [Срок оценки: Through study completion, an average of 1 month]
• EEG Attention Lapse Measures on the Change Detection Task [Срок оценки: Through study completion, an average of 1 month]
• Delivered tDCS Dose to PFC [Срок оценки: Through study completion, an average of 1 month]

Критерии участия

Критерии включения

• between ages of 18 and 50
• ability to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks
• ability to give valid informed consent

Критерии исключения

• no history of head trauma
• no current or previous history of treatment with psychotropic medication
• corrected vision 20/30 or better
• tDCS/MRI contraindications, including: pregnancy, ferrous metal in any part of the body, serious medical conditions, claustrophobia, metallic implants, skin damage, conditions such as eczema at electrode sites, cranial pathologies

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Перекрёстный дизайн

Маскирование

Двойное слепое

Основная цель

Фундаментальное исследование

Центры проведения

США · 1 центр

• Imaging Research Center — Sacramento

Идентификаторы

NCT: NCT04885322 · 1344169-8

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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