Individual Differences in Placebo Analgesic Effects

Официальное название

Person by Situation Interaction: Matching Suggestions to Participants' Motivational Styles

Обзор

This study examines the effects of placebo suggestions tailored to match or mismatch individual participants' motivational styles-an issue of person-situation 'fit' with important effects in public health settings, but which has been ignored in past research.

Вмешательства

• Поведенческое Placebo cream- "promotion" suggestion
  Over-the-counter hand cream will be applied to participants' skin, but they will be told that they are given a highly efficient topical analgesic cream. The suggestion will be based on a "promotion" approach (promoting good feelings).
• Поведенческое Placebo cream- "prevention" suggestion
  Over-the-counter hand cream will be applied to participants' skin, but they will be told that they are given a highly efficient topical analgesic cream. The suggestion will be based on a "prevention" approach (preventing pain).
• Поведенческое Control cream
  In a control condition, with the same cream as in the placebo interventions, participants will be instructed that the cream is a control cream with no effects.

Первичные конечные точки

• Changes in subjective ratings of acute thermal pain [Срок оценки: Measured repeatedly, immediately after thermal stimuli on the day of participation. Averaged and compared across interventions.]
• Changes in subjective ratings of pain expectations [Срок оценки: Measured repeatedly, immediately before thermal stimuli on the day of participation. Averaged and compared across interventions.]

Вторичные конечные точки (4)

• Facial expressions [Срок оценки: Immediate response measured during painful stimulation on the day of participation. Averaged and compared across interventions.]
• Thermal imaging of the face [Срок оценки: Immediate response measured during painful stimulation on the day of participation. Averaged and compared across interventions.]
• Changes in skin conductance response measured with a Biopac device [Срок оценки: Immediate response measured during painful stimulation on the day of participation. Averaged and compared across interventions.]
• Changes in heart rate measured with a Biopac device [Срок оценки: Immediate response measured during painful stimulation on the day of participation. Averaged and compared across interventions.]

Критерии участия

Критерии включения

• Healthy participants
• Dominant promotion focus or dominant prevention focus (based on our screening)

Критерии исключения

• Currently or recently suffered from chronic pain (based on screening)
• Cannot tolerate heat pain applied to the forearm, based on a calibration task at the beginning of the experiment

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Перекрёстный дизайн

Маскирование

Простое слепое

Основная цель

Фундаментальное исследование

Центры проведения

США · 1 центр

• Dartmouth College — Hanover

Идентификаторы

NCT: NCT04669093 · 230138

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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