Идёт набор NCT04651010

Predictive Multimodal MRI Factors in Subacute Cerebral Artery Occlusiontreated by Thrombectomy (PIMISUTT)

Без фазы С лечением Middle Cerebral Artery Acute Ischemic Stroke

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Multimodal MRI.
Кому может быть актуально: Состояния в реестре: Middle Cerebral Artery Acute Ischemic Stroke. Базовые параметры: от 18 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

Predictive Multimodal MRI Factors in Subacute Cerebral Artery Occlusiontreated by Thrombectomy (PIMISUTT

Обзор

Our study aims to measure metabolic and functional parameters of the infarcted territory by multimodal cerebral MRI in patients diagnosed with unilateral proximal occlusion of the middle cerebral artery and treated by thrombectomy in order to correlate those parameters to clinical outcome (evaluated by modified Rankin score) at 3 months. We aim to find early radiologic predictive factors for favorable clinical outcome in this population of patients.

Подробное описание

The treatment of acute ischemic stroke in the setting of intracranial large artery occlusion and especially middle cerebral artery occlusion (MCAO) with intravenous tissue plasminogen activator (IV-tPA) is associated with low rates of recanalization and high rates of neurological morbidity and functional dependence.

In the last few years, endovascular intervention (mechanical thrombectomy) has proven its safety and its efficacy on clinical outcome in patients diagnosed with MCAO and is now commonly recommended.

However, in this population of patients treated by thrombectomy, very few predictive factors, except for the post-procedural recanalization score (TICI), do exist to foresee the variability of clinical outcome.

Tissue viability of the infarcted territory can be approached by the measure of metabolic and morphological parameters (Na+, H+, phosphore, diffusion imaging) which can be non-invasively done by multimodal MRI, as suggest by recently published studies.

Our study plans to measure these parameters between 12 and 24 hours after acute ischemic stroke in patients with MCAO treated by thrombectomy in order to correlate those parameters to clinical outcome at 3 months (modifier Rankin Score).

Вмешательства

Другое Multimodal MRI
Multimodal MRI will be realized between 12 and 24 hours after thrombectomy

Первичные конечные точки

Correlation between modified Rankin score at 3 months and multimodal MRI data [Срок оценки: Month 3]

Вторичные конечные точки (3)

Discharge National Institute of Health Stroke Score (NIHSS) [Срок оценки: Month 3]
National Institute of Health Stroke (NIHSS) score at 3 months [Срок оценки: Month 3]
Change in NIHSS score at 3 months compared to post-thrombectomy [Срок оценки: Month 3]

Критерии участия

Критерии включения

Patients aged ≥ 18 years old
Hospitalized at the Poitiers University Hospital
Acute middle cerebral artery occlusion diagnosed by CT-scan or MRI
NIHSS score ≥ 6 at admission
To be treated by thrombectomy with or without fibrinolysis
Written information delivered to the patient or his relatives concerning the study and its benefit and risk