Идёт набор NCT04625556

Development of Urologic Registry for Personalized Medicine in Patients With Urologic Malignant Diseases by Analyzing Microbiome

— Наблюдательное Urological Malignancies Prostate Cancer Renal Cell Cancer Bladder Cancer

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально: Состояния в реестре: Urological Malignancies, Prostate Cancer, Renal Cell Cancer, Bladder Cancer. Базовые параметры: от 20 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: South Korea
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Genitourinary malignancies such as prostate cancer, renal cell cancer, and bladder cancer in Korean population have been increased due to the aged population and the westernized lifestyles. With the advancement of technologies, studies have found that microbiome not only affects human physiological functions, such as metabolism, immunity, and haematopoiesis, but also plays a significant role in the development and progression of malignancies. However, the investigation of microbiome in urological malignances have been limited and few studies have been reported. Therefore, the investigator tried to evaluate the usefulness of microbiome in detection and monitoring of urological malignancies in Korean population. This study aims to use microbiome in tissue, plasma, stool and urine for the diagnosis, disease progression monitoring and therapeutic response evaluation. This study plan includes building big databases for microbiome of urological malignancies in Korean population.

Первичные конечные точки

Correlation between tissue bacteria composition and prevalence of urological malignancies [Срок оценки: within 2 weeks after the surgery]
Correlation between plasma bacteria composition and prevalence of urological malignancies [Срок оценки: within 2 weeks after the surgery]
Correlation between stool bacteria composition and prevalence of urological malignancies [Срок оценки: within 2 weeks after the surgery]
Correlation between urine bacteria composition and prevalence of urological malignancies [Срок оценки: within 2 weeks after the surgery]

Вторичные конечные точки (1)

Correlation of bacteria composition and tumor response assessed using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) [Срок оценки: within 10 years after the surgery]

Критерии участия

Критерии включения

Patients diagnosed as urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer)
Patients who have undergone surgeries due to urological malignancies in Severance Hospital, Sinchon from 2020.10 and 2030.10
Those who agree to give permission to use their human source information
Those who agree with this study