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Идёт набор NCT04490317

CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)

— Наблюдательное Carbon Monoxide Poisoning Myocardial Injury Neurologic Deficits Image, Body

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Cardiac MRI, Hyperbaric oxygen therapy.
Кому может быть актуально
Состояния в реестре: Carbon Monoxide Poisoning, Myocardial Injury, Neurologic Deficits, Image, Body. Базовые параметры: Без ограничений · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
South Korea
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

This prospective cohort study enrolls subjects who experience carbon monoxide (CO) poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments and short and long-term outcomes in CO poisoned patients. In addition, complications of brain and heart susceptible to CO are investigated through various ways and the association between complications and the patient's prognosis is also investigated. All subjects will be regularly monitored by physicians participating in this study.

Подробное описание

This prospective cohort study enrolls subjects who experience CO poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments, including hyperbaric oxygen therapy (HBO), therapeutic hypothermia (TH), and additional drugs, and short and long-term outcomes, such as neurocognitive sequelae or mortality, in CO poisoned patients. In addition, complications of brain and heart susceptible to CO are investigated through a variety of ways, such as magnetic resonance image (MRI), computed tomography (CT), ultrasound, and laboratory test, and the association between various complications and the patient's prognosis is also investigated. All subjects will be regularly monitored by physicians participating in this study.

Вмешательства

  • Диагностический тест Cardiac MRI
    1. Cardiac MRI be taken to CO poisoned patients 2. Cardiac CT be taken to CO poisoned patients 3. TTE be taken to CO poisoned patients 4. Brain MRI be taken to CO poisoned patients 5. Neurocognitive function tests be taken to CO poisoned patients 6. Laboratory tests be taken to CO poisoned patients
  • Процедура Hyperbaric oxygen therapy
    1. Hyperbaric oxygen therapy be used for CO poisoned patients 2. Therapeutic hypothermia be used for CO poisoned patients

Первичные конечные точки

  • Therapeutic response to HBO at 1 month [Срок оценки: At 1 month after CO exposure]
  • Therapeutic response to HBO at 6 months [Срок оценки: At 6 months after CO exposure]
  • Predictors and model development for participants with poor outcome including mortality, and neurocognitive and psychological sequelae at 1 month after CO exposure evaluated by such as neurocognitive function tests [Срок оценки: Within 1 month after CO exposure]
  • Predictors and model development for participants with poor outcome including mortality, and neurocognitive and psychological sequelae at 6 months after CO exposure evaluated by such as neurocognitive function tests [Срок оценки: Within 1 month after CO exposure]
  • Predictors and model development for participants with poor outcome including mortality, and neurocognitive and psychological sequelae at 12 months after CO exposure evaluated by such as neurocognitive function tests [Срок оценки: Within 1 month after CO exposure]
Вторичные конечные точки (12)
  • Therapeutic response to HBO at 12 months [Срок оценки: At 12 months after CO exposure]
  • Therapeutic response to TH combined with HBO at 1 month [Срок оценки: At 1 month after CO exposure]
  • Therapeutic response to TH combined with HBO at 6 months [Срок оценки: At 6 months after CO exposure]
  • Therapeutic response to TH combined with HBO at 12 months [Срок оценки: At 12 months after CO exposure]
  • Therapeutic response to HBO according to presence of apolipoprotein E4 at 1 month [Срок оценки: At 1 month after CO exposure]
  • Therapeutic response to HBO according to presence of apolipoprotein E4 at 6 months [Срок оценки: At 6 months after CO exposure]
  • Therapeutic response to HBO according to presence of apolipoprotein E4 at 12 months after CO exposure [Срок оценки: At 12 months after CO exposure]
  • Cardiac injury evaluated by cardiac MRI in acute phase [Срок оценки: Within 1 month after CO exposure]
  • Cardiac injury evaluated by cardiac MRI in chronic phase [Срок оценки: Follow-up cardiac MRI (at 4-8 months after CO exposure)]
  • Cardiac injury evaluated by cardiac CT [Срок оценки: Within 1 month after CO exposure]
  • Cardiac injury evaluated by TTE in acute phase [Срок оценки: Within 14 days after CO exposure]
  • Cardiac injury evaluated by TTE in chronic phase [Срок оценки: Within 4-8 months after CO exposure]

Критерии участия

Критерии включения

  • Acute CO poisoning

Критерии исключения

  • Declined to enrollment in the study

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

South Korea · 1 центр
  • Wonju Severance Christian Hospital — Wŏnju

Публикации

  • Ahn GJ, Lee S, Heo YW, Cha YS. Mortality Risks and Causes in Previous Carbon Monoxide Poisoning: A Nationwide Population-Based Cohort Study. Crit Care Med. 2024 Dec 1;52(12):1866-1876. doi: 10.1097/CCM.0000000000006414. Epub 2024 Sep 18. PMID 39298511

Идентификаторы

NCT: NCT04490317 · CARE CO cohort

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗