Toripalimab Plus Concurrent Chemo-radiotherapy for Unresectable Locally Recurrent Nasopharyngeal Carcinoma

Официальное название

A Multicenter Randomized Clinical Phase 3 Trial of Toripalimab Plus Concurrent Chemo-radiotherapy vs Concurrent Chemo-radiotherapy Alone for Unresectable Locally Recurrent Nasopharyngeal Carcinoma

Обзор

Through multicenter, open-label, randomised clinical trials, we intend to demonstrate that concurrent and adjuvant PD-1 treatment added to concurrent chemo-radiotherapy could further decrease the rate of disease progression and improve the survival outcome of patients with unresectable locally recurrent nasopharyngeal carcinoma compared with those treated with concurrent chemo-radiotherapy alone.

Подробное описание

Through multicenter, open-label, randomised clinical trials, patients with unresectable locally recurrent nasopharyngeal carcinoma are randomized into concurrent chemo-radiotherapy plus concurrent and adjuvant PD-1 treatment group and concurrent chemo-radiotherapy alone group. The efficacy and safety of patients between these two groups are compared.

Вмешательства

• Препарат Toripalimab plus concurrent chemo-radiotherapy
  1. Toripalimab: 240 mg, intravenous injection over 60 minutes (Q3W); 2 cycles of toripalimab are concurrently used during radiotherapy and other 9 cycles of toripalimab are used after the end of radiotherapy. (A total of 11 cycles). 2. Concurrent cisplatin chemotherapy: cisplatin is given at a dose of 100 mg/m2 via a continuous intravenous infusion during radiotherapy and starts on the 1st day of radiotherapy for 2 cycles. 1 cycles per 3 weeks. 3. IMRT: PTVnx#60.0Gy/27Fr/2.22Gy; PTVnd# 60-64Gy/2
• Препарат Concurrent chemo-radiotherapy
  1. Concurrent cisplatin chemotherapy: cisplatin is given at a dose of 100 mg/m2 via a continuous intravenous infusion during radiotherapy and starts on the 1st day of radiotherapy for 2 cycles. 1 cycles per 3 weeks. 2. IMRT: PTVnx#60.0Gy/27Fr/2.22Gy; PTVnd# 60-64Gy/27Fr/2.22-2.37Gy; PTV1#54Gy/27Fr/2.00Gy

Первичные конечные точки

• Progress-free survival (PFS) [Срок оценки: 3 years]

Вторичные конечные точки (7)

• Overall Survival (OS) [Срок оценки: 3 years]
• Distant Metastasis-Free Survival (DMFS) [Срок оценки: 3 years]
• Locoregional Relapse-Free Survival (LRRFS) [Срок оценки: 3 years]
• Incidence of treatment related acute complications [Срок оценки: up to 1 years]
• Incidence of treatment related late complications [Срок оценки: up to 3 years]
• Score of survival quality according to the EORTC Quality of Life Questionnaire (QLQ)-C30 (V3.0) [Срок оценки: up to 3 years]
• Score of survival quality according to the EORTC Quality of Life Questionnaire Head and Neck (The QLQ-H&N35) [Срок оценки: up to 3 years]

Критерии участия

Критерии включения

• Histologically confirmed recurrent nasopharyngeal carcinoma.
• The recurrence time is more than 12 months from the end of the first course of radiotherapy.
• Tumor staged as rT2-4N0-3M0，rII-IVa (according to the 8th AJCC edition).
• Subjects must have a measurable disease by CT or MRI per RECIST 1.1 criteria.
• Karnofsky scale (KPS)≥70.
• Normal bone marrow function.
• Normal liver and kidney function:

• total bilirubin, AST and ALT levels of no more than 2.5 times the upper normal limit;
• creatinine clearance rate of at least 60 mL/min or creatinine of no more than 1.5 times the upper normal limit.
• Given written informed consent.

Критерии исключения

• Resectable nasopharyngeal diseases: rT2 (the tumour is confined in the superficial parapharyngeal spacer and is more than 0.5cm from the internal carotid artery) and rT3 (the tumour is confined in the base wall of the sphenoid sinus and is more than 0.5cm from the internal carotid artery and cavernous sinus).
• The patients are suffering from severe nasopharyngeal necrosis, radiation induced brain injury, and fibrosis of the neck et. al, who are evaluated as unsuitable for secondary radiotherapy by the researchers.
• Has known allergy to large molecule protein products or any compound of study therapy.
• Has known subjects with other malignant tumors.
• Has any active autoimmune disease or history of autoimmune disease.
• Has a history of psychiatric substance abuse, alcoholism, or drug addiction.
• The laboratory examination value does not meet the relevant standards within 7 days before enrollment
• Received a systematic glucocorticoid therapy within 4 weeks of the first dose of study medication.
• Has a known history of active TB (bacillus tuberculosis) within 1 year; patients with adequately treated active TB with 1 year.
• Prior therapy with a PD-1, anti-PD-Ligand 1 (PD-L1) or CTLA-4 agent.
• Has active autoimmune disease (e.g., uveitis, enteritis, hepatitis, hypophysitis, nephritis, vasculitis, hyperthyroidism, and asthma requiring bronchodilator therapy). Patients with skin disease that doesn't require systemic treatment (e.g., vitiligo, psoriasis, or alopecia) will be allowed to enroll.
• Has a known history of human immunodeficiency virus (HIV).
• Has hepatitis B surface antigen (HBsAg) positive with HBV DNA copy number of ≥1000cps/ml or hepatitis C virus (HCV) antibody positive
• Has received a live vaccine within 4 weeks of planned start of study therapy
• Pregnancy or breast feeding

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Распределение

Рандомизированное

Модель

Параллельные группы

Маскирование

Открытое

Основная цель

Лечение

Центры проведения

Китай · 6 центров

• Sun Yat-sen University Cancer Center — Гуанчжоу
• Cancer Center of Guangzhou Medical University — Гуанчжоу
• Yuebei People's Hospital — Shaoguan
• Zhongshan People's Hospital — Zhongshan
• The Fifth Affiliated Hospital of Sun Yat-sen University — Zhuhai
• Wuzhou Red Cross Hospital — Wuzhou

Идентификаторы

NCT: NCT04453813 · SYSUCC-MYC-2020-2101

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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