The Effect of Exposure to Aversive Non-verbal Vocalizations on Pain Tolerance

Обзор

Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions. and important social issues. Yet despite their importance in the human vocal repertoire, the mechanisms and functions of non-verbal vocalizations remain little studied and poorly understood including in humans. In this context, the investigators wish to examine how the perception of vocalizations non-verbal aversive behaviours influence pain tolerance in healthy adults.

Подробное описание

Humans produce nonverbal vocalisations such as screams, grunts, roars, cries and laughter across a variety of contexts. Yet despite the prominence and apparent importance of these nonverbal sounds in human communication, the investigators still know very little about their influence on human perception and behaviour. That's why, in this study, the investigators will examine specifically the influence of nonverbal vocal perception on pain tolerance.

The remainder of the study will involve up to three trials of a pain tolerance (cold pressor) task, during which the investigators will ask participants to listen to vocalisations (e.g., babies' cries or babbling) while submerging the participant's hand in bath of circulating cold water.

The results of the study will contribute to theoretical understanding of the functions of nonverbal vocal communication in humans, in particular the influence of nonverbal vocal and perception (of babies' cries) on pain tolerance.

Вмешательства

• Поведенческое Cold pressor task (CPT)
  The cold pressor test is among the most common and established methods for studying human reactions to pain and pain tolerance. Participants submerge a hand in cold water (approx. 5°C) and are asked to keep their hand submerged for as long as can (until the sensation is intolerable), up to a maximum of 5 min. The procedure is safe because the hand is removed before adverse effects can occur. The participant will be given a break of 5 min in between trials, and will interchange hands between t
• Диагностический тест index NOL
  Measurement of the index NOL™: Four sensors, placed non-invasively on one of the four participants' fingers, will make it possible to calculate a dozen physiological parameters converts in real time into a pain index called NOL (for Nociception Level Index).
• Поведенческое Playback Experiments
  During the experience, participants are led to listen, via headphones, to aversive non-verbal vocalizations (baby crying). The sound levels used to broadcast the non-verbal vocalisations will be scrupulously measured using approved and certified equipment during the preparation of the experiments. These sound volumes will be chosen so as not to inconvenience participants.
• Диагностический тест Video-pupillometry
  This technique is based on the observation of the dilatation of the pupil during the perception of a nociceptive stimulus in test persons.

Первичные конечные точки

• Pain tolerance [Срок оценки: at inclusion]

Вторичные конечные точки (3)

• Onset of pain [Срок оценки: at inclusion]
• Pain intensity [Срок оценки: at inclusion]
• Correlation between NOL index and video pupillometry results [Срок оценки: at inclusion]

Критерии участия

Критерии включения

• Participant in good health
• Affiliated or entitled participant in a social security scheme
• Participant who received informed information about the study and co-signed, with the investigator, a consent to participate in the study

Критерии исключения

• Chronic pain
• High blood pressure or poor circulation
• Cardiac or vascular disease, or a heart condition (including symptoms of Raynaud's syndrome)
• Allergy or hypersensitivity to cold
• Diabetes
• Epilepsy
• Pregnancy
• Recent serious injury
• Neurological or psychiatric condition known to affect pain tolerance (e.g., peripheral neuropathy, schizophrenia)
• History of fainting or seizures
• History of frostbite

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Не применимо

Модель

Одна группа

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Франция · 1 центр

• Centre Hospitalier Universitaire SAINT-ETIENNE — Saint-Etienne

Идентификаторы

NCT: NCT04423874 · 19CH215 · 2020-A00274-35

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗