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Идёт набор NCT04342026

Role of the Environment and Endocrine Disruptors in Child Cryptorchidism

— Наблюдательное Cryptorchidism

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors.
Кому может быть актуально
Состояния в реестре: Cryptorchidism. Базовые параметры: 1 мес. — 18 лет · Мужчины.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Франция
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

Подробное описание

Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

Вмешательства

  • Другое Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors
    Measure of the exposure of parent of patient with/without cryptorchidism to endocrine disruptors (job exposure, during pregnancy)

Первичные конечные точки

  • frequency of the job exposure of the parents of endocrine disruptors [Срок оценки: 1 day]
Вторичные конечные точки (4)
  • comparison of cryptorchid and non-cryptorchid children born to parents with isolated exposure vs multiple exposures [Срок оценки: 1 day]
  • Comparison of frequencies of exposure to endocrine disruptors (Environmental Disrupting Chemicals) in parents giving birth to a congenital cryptorchid child vs child not cryptorchid at birth but with secondary cryptorchidism. [Срок оценки: 1 day]
  • identify food exposure criteria (phytoestrogen or EDC pesticides) associated with the presence of a cryptorchid. [Срок оценки: 1 day]
  • Constitution of collection of biological samples from children with non-palpable bilateral cryptorchidism [Срок оценки: 1 day]

Критерии участия

Критерии включения

\- Parents of male children from the neonatal period to 18 years of age (during surgery) with cryptorchidism

Критерии исключения

  • Parents of children without endocrine disease. (adrenal, hypothalamic-pituitary, phosphocalcic, thyroid, diabetes, etc.)
  • Parents of children without an associated genital or urinary defect (hypospadias, micropenis, renal and bladder abnormalities)
  • Testicular Ectopia (testis outside of normal migration path)
  • Anorchidism and evanescent testicles, united or bilateral
  • Abnormalities of the abdominal wall (laparoschisis, omphalocele, Prune Belly)
  • Cryptorchidism integrating in the context of a polymalformative syndrome, including neurological.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения
Случай-контроль

Центры проведения

Франция · 1 центр
  • University hospital of Montpellier — Montpellier

Идентификаторы

NCT: NCT04342026 · RECHMPL19_0544

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗