Magnetic Resonance Imaging In Acute ST-Elevation Myocardial Infarction

Официальное название

Clinical Relevance of Magnetic Resonance Imaging in Acute ST-Elevation Myocardial Infarction

Обзор

Cardiovascular magnetic resonance imaging enables comprehensive assessment of cardiovascular function, morphology and pathology. The investigators aim to evaluate the nature and clinical significance of magnetic resonance imaging parameters in patients presenting with first acute ST-elevation myocardial infarction.

Вмешательства

• Диагностический тест Cardiovascular Magnetic Resonance Imaging
  Cardiovascular magnetic resonance imaging will be performed within the first week after ST-elevation myocardial infarction and in a defined subgroup 4 months, 12 months and 10 years thereafter.

Первичные конечные точки

• Occurence of major adverse cardiovascular events [Срок оценки: 1 - 5 years]

Вторичные конечные точки (12)

• Infarct size assessment (% of left ventricular myocardial mass) [Срок оценки: baseline, 4 months and 12 months]
• Assessment of infarct transmurality grade (%) with late gadolinium enhancement imaging [Срок оценки: baseline, 4 months and 12 months]
• Occurence and area of microvascular obstruction [Срок оценки: baseline]
• Intramyocardial haemorrhage assessed by T2* imaging [Срок оценки: baseline, 4 months and 12 months]
• Tissue characterisation by T1, T2 and T2* Mapping [Срок оценки: baseline, 4 months and 12 months]
• Myocardial deformation by strain analysis [Срок оценки: baseline, 4 months and 12 months]
• Chamber volumes by cine imaging [Срок оценки: baseline, 4 months and 12 months]
• Cardiac function by cine imaging [Срок оценки: baseline, 4 months and 12 months]
• Stroke volumes by phase contrast imaging [Срок оценки: baseline, 4 months and 12 months]
• Aortic pulse wave velocity and distensibility by phase contrast imaging [Срок оценки: baseline, 4 months and 12 months]
• Aortic pulse wave distensibility by phase contrast imaging [Срок оценки: baseline, 4 months and 12 months]
• Quality of life and invalidity assessment (Global Physical Activity Questionnaire) [Срок оценки: 1 - 5 years]

Критерии участия

Критерии включения

• First ST-elevation myocardial infarction according to the European Society of Cardiology/American College of Cardiology committee criteria
• Primary percutaneous coronary intervention within 24 hours after symptom onset

Критерии исключения

• Age < 18 years
• Any history of a previous myocardial infarction or coronary intervention
• Clinically unstable patients (Killip class >2)
• Renal failure (estimated glomerular filtration rate < 30 ml/min/1.73 m2)
• Contraindications to cardiac magnetic resonance imaging (pacemaker, cerebral aneurysm clip, orbital foreign body, known or suggested contrast allergy to gadolinium, claustrophobia)
• Inability to provide informed consent

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Австрия · 2 центра

• University Hospital for Internal Medicine III (Cardiology and Angiology) — Innsbruck
• University Hospital for Radiology — Innsbruck

Публикации

• Schwab M, Pamminger M, Kremser C, Almar-Munoz E, Reinstadler SJ, Reindl M, Metzler B, Haltmeier M, Mayr A. Association of Deep Learning-based Myocardial Infarction Size Quantification in Cardiac MRI with Cardiac Biomarker Levels. Radiol Cardiothorac Imaging. 2026 Jun;8(3):e250235. doi: 10.1148/ryct.250235. PMID 42347575
• Lechner I, Reindl M, von der Emde S, Desheva A, Oberhollenzer F, Tiller C, Holzknecht M, Kremser T, Faccini J, Gollmann-Tepekoylu C, Kremser C, Mayr A, Bauer A, Metzler B, Reinstadler SJ. Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications. Circ Cardiovasc Imaging. 2024 Dec;17(12):e017041. doi: 10.1161/CIRCIMAGING.124.017041. Epub 2024 Nov 29. PMID 39611252
• Tiller C, Holzknecht M, Lechner I, Oberhollenzer F, von der Emde S, Kremser T, Gollmann-Tepekoylu C, Mayr A, Bauer A, Metzler B, Reinstadler SJ, Reindl M. Association of Circulating PCSK9 With Ischemia-Reperfusion Injury in Acute ST-Elevation Myocardial Infarction. Circ Cardiovasc Imaging. 2024 Aug;17(8):e016482. doi: 10.1161/CIRCIMAGING.123.016482. Epub 2024 Aug 20. PMID 39163371
• Holzknecht M, Tiller C, Reindl M, Lechner I, Fink P, Lunger P, Mayr A, Henninger B, Brenner C, Klug G, Bauer A, Metzler B, Reinstadler SJ. Association of C-Reactive Protein Velocity with Early Left Ventricular Dysfunction in Patients with First ST-Elevation Myocardial Infarction. J Clin Med. 2021 Nov 24;10(23):5494. doi: 10.3390/jcm10235494. PMID 34884196
• Tiller C, Reindl M, Holzknecht M, Lechner I, Schwaiger J, Brenner C, Mayr A, Klug G, Bauer A, Metzler B, Reinstadler SJ. Association of plasma interleukin-6 with infarct size, reperfusion injury, and adverse remodelling after ST-elevation myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2022 Feb 8;11(2):113-123. doi: 10.1093/ehjacc/zuab110. PMID 34849677
• Lechner I, Reindl M, Tiller C, Holzknecht M, Niederreiter S, Mayr A, Klug G, Brenner C, Bauer A, Metzler B, Reinstadler SJ. Determinants and prognostic relevance of aortic stiffness in patients with recent ST-elevation myocardial infarction. Int J Cardiovasc Imaging. 2022 Jan;38(1):237-247. doi: 10.1007/s10554-021-02383-0. Epub 2021 Sep 2. PMID 34476665
• Reindl M, Lechner I, Tiller C, Holzknecht M, Rangger A, Mayr A, Theurl M, Klug G, Brenner C, Bauer A, Metzler B, Reinstadler SJ. Glycemic Status and Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction. JACC Cardiovasc Imaging. 2021 Sep;14(9):1875-1877. doi: 10.1016/j.jcmg.2021.04.007. Epub 2021 May 19. No abstract available. PMID 34023265
• Reindl M, Tiller C, Holzknecht M, Lechner I, Eisner D, Riepl L, Pamminger M, Henninger B, Mayr A, Schwaiger JP, Klug G, Bauer A, Metzler B, Reinstadler SJ. Global longitudinal strain by feature tracking for optimized prediction of adverse remodeling after ST-elevation myocardial infarction. Clin Res Cardiol. 2021 Jan;110(1):61-71. doi: 10.1007/s00392-020-01649-2. Epub 2020 Apr 15. PMID 32296969

Идентификаторы

NCT: NCT04113356 · AN3775

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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