Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans

Обзор

Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature. This investigation seeks to determine the role of dietary potassium on the vasculature in the presence of a high sodium diet in salt-resistant adults.

Подробное описание

Significant public health efforts have been made towards salt reduction but most have met with failure. Dietary factors such high sodium/low potassium diets contribute to the development of cardiovascular diseases (CVDs) such as atherosclerosis and high blood pressure (BP). This is important as CVD is the number one killer in the U.S. While the role of these two nutrients on BP is widely accepted, their impact on the vasculature has received less attention. Endothelial dysfunction, characterized by impaired dilation, is an important non-traditional risk factor for atherosclerosis. Evidence supporting potassium's beneficial role on vascular health remains unclear although it may be more effective in the presence of a high sodium diet. A purported mechanism responsible for sodium-induced vascular dysfunction is overproduction of reactive oxygen species (ROS) resulting in reduced nitric oxide (NO) production/bioavailability. Additionally, high sodium diets have been shown to stiffen the endothelium. This investigation will evaluate the vascular effects of dietary potassium during a high salt diet including its impact on sodium-induced oxidative stress and endothelial cell stiffness.

Вмешательства

• Другое Moderate Potassium/Low Sodium Diet
  Consumption of 10 days of a diet moderate in potassium and low in sodium.
• Другое Moderate Potassium/High Sodium Diet
  Consumption of 10 days of a diet moderate in potassium and high in sodium.
• Другое High Potassium/High Sodium Diet
  Consumption of 10 days of a diet high in potassium and high in sodium.

Первичные конечные точки

• Conduit artery endothelial-dependent dilation [Срок оценки: on day 10 of the diet]
• Microvascular function [Срок оценки: on day 10 of the diet]

Вторичные конечные точки (1)

• Ambulatory BP monitoring [Срок оценки: on day 7 and 10 of diet]

Критерии участия

Критерии включения

• healthy
• normal blood pressure
• normal resting ECG

Критерии исключения

• hypertension
• history of heart disease
• diabetes
• kidney disease
• obese (BMI ≥30)
• significant weight changes in the last 6 months
• use of tobacco products
• pregnant
• on a special diet (gluten free; vegan)
• take any medications for the above conditions
• endurance trained athletes

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Перекрёстный дизайн

Маскирование

Открытое

Основная цель

Профилактика

Центры проведения

США · 1 центр

• University of Delaware — Newark

Идентификаторы

NCT: NCT04101188 · 1472577 · 5R01HL145055-05

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗