Molecular Basis of Pediatric Liver Cancer
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Childhood Liver Cancer, Liver Malignant Tumors, Embryonal Sarcoma of Liver (Disorder), Hepatoblastoma. Базовые параметры: 0 лет — 99 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- США
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Не всё понятно в терминах? Прочитайте наш гид для пациентов →
Официальное название
Genetic and Molecular Basis of Pediatric Liver Cancer
Обзор
The purpose of this retrospective and prospective project is to understand the molecular and genetic basis of liver cancer of childhood. Understanding the molecular and genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.
Подробное описание
Pediatric liver cancers are rare, affecting at times no more than 1 in one million population. Understanding the molecular basis of these cancers is important in order to develop more accurate diagnoses and more effective treatments. Current classifications of these cancers are based on how these cancers look on diagnostic studies such as radiologic imaging or under the microscope. Such a classification system does not explain why a particular cancer has a different outcome from what is considered "usual" for that particular cancer. Nor does such a classification system explain why two different classes of cancers behave the same way. Understanding the genetic bases of liver cancers can offer a better classification based on tumor biology, mechanisms and predisposition.
To achieve these goals, large numbers of such cancer patients or affected tissue must be collected. This is not possible in any single institution, or any single country. The current project will collect biological samples such as residual tumor tissue, saliva, or blood from affected patients and their biological parents and families, along with clinical information about the cancer. These biological samples will be used to study the genes and how these genes work in tumor tissue and in non-tumor tissue. The results of this study will permit childhood liver cancers to be categorized on the basis of common defects in genes and their function.
Первичные конечные точки
- Gene sequencing [Срок оценки: Recurrence free survival at 2 years]
- Gene expression analysis [Срок оценки: Recurrence free survival at 2 years]
- Status of genome-wide chromatin accessibility [Срок оценки: Duration of active chemotherapy to two years after surgical treatment]
- Epigenetic change [Срок оценки: Duration of active chemotherapy to two years after surgical treatment]
- Tumor infiltrating cells which express immune checkpoints [Срок оценки: Duration of active chemotherapy to two years after surgical treatment]
Вторичные конечные точки (2)
- Response to chemotherapy [Срок оценки: Duration of active chemotherapy to two years after surgical treatment]
- Response to chemotherapy [Срок оценки: Duration of active chemotherapy to two years after surgical treatment]
Критерии участия
Критерии включения
- Prior or current treatment for a childhood liver tumor, malignant or benign, at age <21 years.
- Biological parents and siblings of eligible children.
Критерии исключения
- No prior or current treatment for a childhood liver tumor.
- Non-biological parents, legal guardians, or non-biological siblings of eligible children.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Модель наблюдения
- Другое
Центры проведения
США · 1 центр
- UPMC Children's Hospital of Pittsburgh — Pittsburgh
Идентификаторы
NCT: NCT03959800 · STUDY20050018