Registry Study on Prescription, Patient Pathways, Therapy Efficacy and Usage of Mandibular Advancement Devices in Obstructive Sleep Apnea - PATT-OSA Registry

During sleep, the muscles in the oropharyngeal space relax, the tongue falls back and the volume of the pharynx decreases. Air cannot pass through as it would in the awake state and thus airflow limitations occur. Diminishing airflow can lead to snoring or to the airways collapsing completely (obstructive sleep apnea, OSA). Patients who suffer from OSA have trouble breathing during sleep and will have a disturbed sleep architecture as repeated airway closure causes wake reactions and arousals. This does not only lead to severe daytime sleepiness with high risk of causing car accidents, for instance, but also affects synaptic activity during sleep and the balance of blood gas levels. These factors can have a aggravating effect on blood pressure and worsen the prognosis for cardiovascular comorbidities. First line therapy for obstructive sleep apnea (OSA) is positive airway pressure (PAP) that keeps the airways open with a pneumatic splint. Positive airway pressure is being applied through a facial mask and some patients cannot tolerate this therapy or refuse it. An alternative treatment approach is by fitting an MAD that the patient wears during sleep. An MAD pushes the lower jar forward and thereby increases the volume of the upper airways, thus preventing them to close. Studies have shown good compliance with MAD therapy and benefits in terms of sleepiness and quality of life. The Narval registry study aims to investigate MAD usage in real life and reasons for non-compliance. The registry aims to record patient characteristics (e.g. comorbidities) and side effects that lead to a termination of therapy, but also how the costs for therapy are split between the patient and public or private health insurance providers and how this affects therapy initiation and usage.

• Changes in sleep-related quality of life from baseline compared to 3 months follow-up [Срок оценки: 3 months]
• Changes in daytime sleepiness from baseline compared to 3 months follow-up [Срок оценки: 3 months]
• Changes in snoring from baseline compared to 3 months follow-up [Срок оценки: 3 months]
• Usage of the MAD (mandibular advancement device) [Срок оценки: 3 months]
• Side effects with use of the MAD (mandibular advancement device) [Срок оценки: 3 months]
• Document comorbidities of enrolled patients [Срок оценки: 3 months]
• Remuneration of a MAD [Срок оценки: 3 months]
• Satisfaction with therapy [Срок оценки: 3 months]
• Document sleep disorders of enrolled patients [Срок оценки: 3 months]
• Continuation of therapy [Срок оценки: 3 months]