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Идёт набор NCT03900910

Gastric Cancer Prevention for Indigenous Peoples

Без фазы С лечением Gastric Cancer

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
В протоколе указаны: Gastric cancer prevention, Execution of the program.
Кому может быть актуально
Состояния в реестре: Gastric Cancer. Базовые параметры: 20 лет — 60 лет · Все.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Тайвань
Следующий шаг
Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Официальное название

A Gastric Cancer Prevention Program for Aboriginal People Living in the Remote Areas

Обзор

The incidence of gastric cancer in local indigenous peoples is higher than the non-Indigenous counterpart in Taiwan. How to design an effective prevention strategy for gastric cancer is of importance. The present study aimed to identify the causes that may account for the health inequalities, allowing generation of a plan of action on the whole population scale.

Подробное описание

Owing to the continuing gap in cancer burden between Indigenous and non-Indigenous peoples, reducing health disparities has drawn worldwide attention. Evidence indicates that the gastric cancer incidence and mortality rates in Indigenous peoples are much higher than those of non-Indigenous counterparts living in the same areas. Exposure to more risk factors from social habits, lifestyle, and Helicobacter pylori infection has been considered the cause. However, even though gastric cancer has been repeatedly shown to be preventable by eliminating risk factors, eradication policies are rarely designed for Indigenous peoples. Possible obstacles may include the lack of Indigenous health statistics, inadequate access to care, difficulty in modifying social habits and lifestyles, and the presence of environmental and cultural barriers. Developing and implementing a preventive strategy following the evidence-based principle remains a challenge.

In Taiwan, the number of Indigenous peoples has grown; however, their life expectancy remains substantially lower than that of the non-Indigenous population. Cancer is the most prevalent cause of death for Indigenous peoples and a disproportionate prevalence of certain kinds of cancer is noted for Indigenous peoples. These observations provide an opportunity to establish a plan of action, in which a specific intervention is developed to decrease the threat from each specific cancer so that the overall disparate burden can be reduced in a stepwise manner.

Вмешательства

  • Другое Gastric cancer prevention
    Participants will receive the 13C-urea breath test and those with test positive will further receive H. pylori eradication treatment.
  • Другое Execution of the program
    Screening program is audited by the standardized quality indicators, including the participation rate, the positivity rate, the referral-to-treatment rate, and the eradication rate .

Первичные конечные точки

  • Gastric cancer incidence [Срок оценки: After at least 5 years, the gastric cancer incidence per 100,000 person-years is calculated by the person-years of follow-up.]
  • Helicobacter eradication rate [Срок оценки: At least 5 years]
  • The participation rate [Срок оценки: Screening program quality indicator]
  • The positivity rate [Срок оценки: Screening program quality indicator]
  • The referral-to-treatment rate [Срок оценки: Screening program quality indicator]
  • The reinfection rate [Срок оценки: Screening program quality indicator]

Критерии участия

Критерии включения

  • Aged 20-60 years
  • Mentally competent to be able to understand the consent form
  • Able to communicate with study staff for individuals

Критерии исключения

  • Pregnancy
  • Individuals with major comorbid diseases

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение
Нерандомизированное
Модель
Одна группа
Маскирование
Открытое
Основная цель
Профилактика

Центры проведения

Тайвань · 1 центр
  • National Taiwan University Hospital — Taipei

Публикации

  • Lei WY, Lee JY, Chuang SL, Bair MJ, Chen CL, Wu JY, Wu DC, Tien O'Donnell F, Tien HW, Chen YR, Chiang TH, Hsu YH, Hsu TH, Hsieh PC, Lin LJ, Chia SL, Wu CC, Subeq YM, Wen SH, Chang HC, Lin YW, Sun KP, Chu CH, Wu MS, Graham DY, Chen HH, Lee YC. Eradicating Helicobacter pylori via 13C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development o PMID 37197905

Идентификаторы

NCT: NCT03900910 · 201804108RINB · 1070056368

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗