Study of Individuals Affected With Hypoplasminogenemia

Официальное название

Hypoplasminogenemia: An International RetroSpecTive and PrOspective CohoRt StudY (HISTORY)

Обзор

This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities

Подробное описание

The aims of this study are to:

1. Define PLGD natural history in a large cohort of individuals with hypoplasminogenemia and their first-degree family members. 2. Identify factors that correlate with disease expression and severity. 3. Create a specimen biobank for further studies, available to other researchers.

The project will be international in scope with two collaborating centers that have created and will collect the subject data and samples. In North/Central/South America, the Indiana Hemophilia \& Thrombosis Center (IHTC) will serve as the primary site while University of Milan will serve as the center for all other sites. The database is housed at the University of Milan, Italy.

Study population will include males and females affected with hyposplasminogenemia of any age. Both one-year retrospective and three-year prospective data will be collected on an international cohort of 100 affected individuals and their first degree family members (parents, siblings; total estimated study population \~500).

Study sample analysis, except for urine analyses, will be centralized and performed in Italy; the plasminogen antibody analysis will be batched for analysis, and the urine analyses will be performed locally. A sample biorepository will be created and ultimately housed in Italy. The study will provide testing for plasminogen activity and antigen, plasminogen genetic analysis, polymorphisms in genes that impact plasminogen expression and fibrinolysis, and global hemostatic assays. In addition, stored samples will be used for further testing and analyses to potentially include whole genome sequencing to further identify plasminogen genetic mutations as needed and to investigate other genetic modifiers of disease expression. An exploratory aim includes investigating the potential relationship with streptococcal strains and altered plasminogen products.

The study period will be 3 years for each enrolled subject. In-person visits will be conducted and samples for analysis will be collected at baseline and at end of study. Interval follow-up will be performed every 6 months by telephone. data will be collected at unscheduled visits that are performed for clinical need at the treating physician's discretion.

Первичные конечные точки

• Define the natural history of plasminogen deficiency [Срок оценки: 2 years]
• Identify factors that contribute to or correlate with disease expression and severity [Срок оценки: 5 years]
• Create a specimen biobank [Срок оценки: 15 years]

Критерии участия

Критерии включения

• Signed informed consent and assent as applicable (Appendix 1)
• A. Males or females with type 1 PD diagnosed locally with plasminogen activity levels <50% OR B. First degree family members of a person diagnosed with type 1 PD (includes parents, siblings, half-siblings)
• All ages included
• Available clinical history and treatment for at least 1 year prior to entry except for infants < 1 year of age
• Willingness to provide samples for analysis including DNA, plasma etc.
• Willingness to participate in prospective follow-up for up to 3 years

Критерии исключения

• Previous organ transplant recipient
• Any psychiatric disorder, other mental disorder, or any other medical disorder that impairs the subject's ability to give informed consent or to comply with the requirements of the study protocol
• Refuses to provide informed consent
• Special patient populations, including prisoners or, are deemed medically or cognitively unsuitable for research by their treating physician
• Inability to obtain a blood sample due to poor or limited venous access

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

США · 13 центров

• The University of Alabama (UAB) — Birmingham
• Rush University Medical Center — Chicago
• Indiana Hemophila @Thrombosis Center — Indianapolis
• University of Minnesota, Pediatric Hem/Onc & Cancer Survivorship Program — Minneapolis
• Stony Brook University | Stony Brook Medicine — East Setauket
• SUNY Upstate Medical University, Pediatric Hematology/Oncology — Syracuse
• University of North Carolina at Chapel Hill — Raleigh
• Wake Forest University — Winston-Salem
• … и ещё 5 центров

Turkey (Türkiye) · 6 центров

• Dokuz Eylul University pediatric Pulmonology, Allergy and Clinical Immunology — Izmir
• Uludag University, Medical Faculty Sebahattin Gazioğlu, Pediatric Hematology and Oncology — Bursa
• Ondokuz Mayıs Üniversitesi Tıp Fakültesi Pediatrik Hematoloji Bölümü — Samsun
• Istanbul Üniversitesi Onkoloji Enstitüsü — Istanbul
• Istanbul University Cerrahpsasa, Cerrahpsasa Medical Faculty Pediatric Hematology and Onco — Istanbul
• Yuzuncu Yil University Faculty of Medicine Department of Ophthalmology — Van

Канада · 4 центра

• Windsor Regional Hospital — Windsor
• CHU Sainte-Justine — Montreal
• CHU de Québec Université Laval — Québec
• University of Saskatchewan — Saskatoon

Великобритания · 3 центра

• Cardiff and Vale UHB — Cardiff
• Great Ormond Street Hospital for Children NHS Foundation Trust — London
• Royal Free Hospital, Royal Free London NHS Foundation Trust — London

Австралия · 2 центра

• Murdoch Children's Research Institute, The Royal Children's Hospital — Melbourne
• Children's Health Queensland Hospital and Health Service — South Brisbane

Италия · 2 центра

• Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, — Milan
• University Hospital of Padova — Padua

Аргентина · 1 центр

• Hospital Britanico Buenos Aires — Buenos Aires

Австрия · 1 центр

• Medical University of Innsbruck, University Clinic for Pediatrics and Adolescent Medicine — Innsbruck

Греция · 1 центр

• Alexandra Hospital, Athens, Hematology Department — Athens

Израиль · 1 центр

• Safra's Children Hospital, Sheba Medical Center — Tel Aviv

Таиланд · 1 центр

• Faculty of Medicine, Chiang Mai University — Chiang Mai

Публикации

• Shapiro AD, Menegatti M, Palla R, Boscarino M, Roberson C, Lanzi P, Bowen J, Nakar C, Janson IA, Peyvandi F. An international registry of patients with plasminogen deficiency (HISTORY). Haematologica. 2020 Mar;105(3):554-561. doi: 10.3324/haematol.2019.241158. Epub 2020 Jan 30. PMID 32001536
• Tait RC, Walker ID, Conkie JA, Islam SI, McCall F, Mitchell R, Davidson JF. Plasminogen levels in healthy volunteers--influence of age, sex, smoking and oral contraceptives. Thromb Haemost. 1992 Nov 10;68(5):506-10. PMID 1455395
• Schuster V, Hugle B, Tefs K. Plasminogen deficiency. J Thromb Haemost. 2007 Dec;5(12):2315-22. doi: 10.1111/j.1538-7836.2007.02776.x. Epub 2007 Sep 26. PMID 17900274
• Ma Q, Ozel AB, Ramdas S, McGee B, Khoriaty R, Siemieniak D, Li HD, Guan Y, Brody LC, Mills JL, Molloy AM, Ginsburg D, Li JZ, Desch KC. Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels. Blood. 2014 Nov 13;124(20):3155-64. doi: 10.1182/blood-2014-03-560086. Epub 2014 Sep 10. PMID 25208887
• Celkan T. Plasminogen deficiency. J Thromb Thrombolysis. 2017 Jan;43(1):132-138. doi: 10.1007/s11239-016-1416-6. PMID 27629020
• Shapiro AD, Nakar C, Parker JM, Albert GR, Moran JE, Thibaudeau K, Thukral N, Hardesty BM, Laurin P, Sandset PM. Plasminogen replacement therapy for the treatment of children and adults with congenital plasminogen deficiency. Blood. 2018 Mar 22;131(12):1301-1310. doi: 10.1182/blood-2017-09-806729. Epub 2018 Jan 10. PMID 29321155
• Sang Y, Menegatti M, Brody JA, Wiggins KL, Cooley BC, Kapfer KN, Kangro K, de Laat B, Peyvandi F, Flick MJ, Smith NL, Shapiro AD, Wolberg AS. Plasminogen activation and plasmin activity are not necessary to prevent venous thrombosis/thromboembolism. Blood. 2025 Sep 11;146(11):1346-1358. doi: 10.1182/blood.2025028680. PMID 40403316

Идентификаторы

NCT: NCT03797495 · HISTORY

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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