Pitch Perception and Memory: Deficits and Training

Обзор

Pitch perception and memory are central in auditory cognition, in particular for sound source segregation and recognition, speech prosody and music processing. Here the investigator assess pitch perception and memory in hearing-impaired listeners wearing cochlear implant(s) and listeners with congenital amusia, both compared with control listeners. Behavioral, EEG, and MEG measures are collected in audio and audio-visual contexts to characterize pitch processing deficits, and test a pitch training program.

Вмешательства

• Поведенческое Listening tests. Pitch training protocol
  The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.
• Поведенческое visuo-spatial training protocol
  The two training protocols consists of perceptual tasks (auditory or visual exercises) performed repetitively using a tablet. Each protocol consists in 30 sessions of \~20 minutes performed at home over a period of 15 weeks.
• Поведенческое EEG/MEG/MRI recordings.
  Listening tests. EEG/MEG/MRI recordings

Первичные конечные точки

• percentages of correct responses in listening tests [Срок оценки: during procedure]
• reaction times in listening tests [Срок оценки: during procedure]
• Event-Related Fields [Срок оценки: during procedure]
• Oscillations [Срок оценки: during procedure]

Вторичные конечные точки (6)

• percentages of correct responses [Срок оценки: Day 0]
• percentages of correct responses [Срок оценки: Day 0]
• reaction times [Срок оценки: Day 0]
• reaction times [Срок оценки: Day 0]
• Event-Related Fields [Срок оценки: Day 0]
• Oscillations [Срок оценки: Day 0]

Критерии участия

Критерии включения

For adult participants:

• Aged between 18 and 90
• Absence of neurological and psychiatric disorders
• No major cognitive deficit, ability to understand and apply study instructions
• Motivation to participate efficiently in the study
• Written informed consent to participant in the study
• Affiliated to social security
• Control participants and participants with congenital amusia for Experiment 5: MRI/MEG compatibility

For underage participants:

• Subject aged 5 years and over
• Informed consent of parents or guardians for the participation of the child being studied
• No neurological or psychiatric history
• Without major cognitive impairment and ability to understand and apply setpoint.
• Subject affiliated to a social security scheme
• Motivation to participate effectively in the project

Критерии исключения

For adult participants:

• Age below 18 or above 90
• Pregnant or breast-feeding woman

For underage participants:

\- Pregnant or nursing minors

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Перекрёстный дизайн

Маскирование

Открытое

Основная цель

Фундаментальное исследование

Центры проведения

Франция · 1 центр

• Lyon Neuroscience Research Center — Bron

Идентификаторы

NCT: NCT03707691 · 69HCL18_0632 · 2018-A02670-55

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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