Preterm Birth Cohort Study in Guangzhou

Preterm birth has become the leading cause of neonatal death and the second leading cause of death among children under five years of age. Preterm childrens are more susceptible to adverse health problems including brain injury and neurodevelopment delay, and are at risk of chronic diseases which could impair the health status and life quality later in life. However, the causes of preterm birth is still not clear, and there are no effective prediction and preventive strategies. The Preterm Birth Cohort Study in Guangzhou (PBCSG) will collect the epidemiological,clinical information and biological specimens including maternal blood,cord blood, placenta, children's blood and stool samples of preterm childrens and their mothers. More importantly, childrens' health status, physical and neurodevelopment will be followed up to late childhood and adolescence. The preterm birth cohort would help to explore the mechanism of preterm birth and to examine the short- and long-term influence of preterm birth on physical health and neurodevelopment of childrens.

• Intelligence quotient of offspring [Срок оценки: At age of 6 years old]
• Height changes during childhood and adolescence [Срок оценки: At birth, age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 year]
• Weight changes during childhood and adolescence [Срок оценки: At birth, age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 year]
• Change of intestinal flora during early childhood [Срок оценки: At age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 years old]
• Changes of body fat percentage during early childhood [Срок оценки: At age of 3 years, 6 years, 12 years and 18 years old]
• Changes of bone density during early childhood [Срок оценки: At age of 3 years, 6 years, 12 years and 18 years old]