IVF Offspring Born in Guangzhou
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: ART, Offspring, Adult, Genetics, Host and Microbiome. Базовые параметры: до 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Китай
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Не всё понятно в терминах? Прочитайте наш гид для пациентов →
Официальное название
IVF Offspring Born in Guangzhou Cohort Study
Обзор
The IVF Offspring Born in Guangzhou Cohort Study (IVF-BIG) was established to investigate the short- and long-term effects of exposure in early life on the health of mothers and offspring in Guangzhou, China. Data are collected regarding assisted reproductive technology (ART), environmental, occupational and lifestyle exposures as well as health outcomes in their later life. Biological samples including blood and tissue samples are also collected from participants.
Подробное описание
It has been 40 years since the first IVF baby born in the world. The effects of hormonal drugs used on women and health of IVF offspring have always been concerned in the reproductive field and in public. With the increase of the prevalence of infertility and development of ART, China is facing a IVF babies boom. It has been reported that ART was associated with higher risk of cancers among women undergoing treatment of ART, and an increased incidence of autism and noncommunicable chronic diseases, such as obesity, among IVF offspring. Epigenetics is documented as one of the possible mechanisms, while answers remain to be explored. A birth cohort would provide an opportunity to examine the short- and long-term effects of ART exposure on health consequences of the mothers and babies.
Первичные конечные точки
- Intelligence quotient of offspring [Срок оценки: At age of 6 years old]
Вторичные конечные точки (8)
- Prevalence of gestational diabetes, pregnancy induced hypertension, and cesarean section [Срок оценки: From 20 weeks of gestation to delivery]
- Prevalence of stillbirth, preterm birth, small for gestational age, large for gestational age and birth defect [Срок оценки: At delivery]
- Neurodevelopment at early childhood [Срок оценки: At age of 1 year old]
- Epegenetic profiles of offspring [Срок оценки: At age of 1 year, 6 years, 12years and 18 years old]
- Changes of body composition and bone density during early childhood [Срок оценки: At age of 3 years,6 years, 12 years and 18 years old]
- Height changes during early childhood [Срок оценки: At birth, age of 6 weeks, 6 months, 1 year and 3 years old]
- Weight changes during early childhood [Срок оценки: At birth, age of 6 weeks, 6 months, 1 year and 3 years old]
- Change of intestinal flora during early childhood [Срок оценки: At age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 years old]
Критерии участия
Критерии включения
- Pregnant women with <20 weeks of gestation
- Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
- Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years
- Pregnant women conceived by assited reproductive technology
Критерии исключения
- None
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Китай · 1 центр
- Guangzhou Women and Children's Medical Center — Гуанчжоу
Публикации
- Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20. PMID 28321694
Идентификаторы
NCT: NCT03650829 · 2018080103