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Идёт набор NCT03633162

Maternal Grandmothers in the Born in Guangzhou Cohort Study

— Наблюдательное Hereditary Transmission Immune Development Childhood Obesity Host and Microbiome

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально
Состояния в реестре: Hereditary Transmission, Immune Development, Childhood Obesity, Host and Microbiome. Базовые параметры: 36 лет — 100 лет · Женщины.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Китай
Следующий шаг
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Обзор

The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.

Подробное описание

It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.

Вмешательства

  • Другое

Первичные конечные точки

  • Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring [Срок оценки: From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth]
Вторичные конечные точки (7)
  • Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life [Срок оценки: At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren]
  • The prevalence of eczema of grandchildren [Срок оценки: At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren]
  • The incidence of asthma of grandchildren [Срок оценки: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren]
  • The prevalence of Allergic rhinitis of grandchildren [Срок оценки: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren]
  • The prevalence of Food allergy of children and grandchildren [Срок оценки: At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren]
  • Changes of body composition of grandchildren [Срок оценки: At age of 3 years,6 years, 12years and 18years]
  • Changes of bone density of grandchildren [Срок оценки: At age of 3 years,6 years, 12years and 18years]

Критерии участия

Критерии включения

  • Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
  • Baseline information of maternal grandmother's daughter during pregnancy available

Критерии исключения

  • Significant cardiovascular abnormalities
  • Intelligent obstacle, intellectual disabilities or gawkish condition

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Китай · 1 центр
  • Guangzhou Women and Children's Medical Center — Гуанчжоу

Публикации

  • Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20. PMID 28321694
  • Kinder JM, Jiang TT, Ertelt JM, Xin L, Strong BS, Shaaban AF, Way SS. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 Jul 30;162(3):505-15. doi: 10.1016/j.cell.2015.07.006. Epub 2015 Jul 23. PMID 26213383

Идентификаторы

NCT: NCT03633162 · 2018041801 · 81673181 · 201508030037

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗