Birth Cohort Study of China Medical University

Официальное название

Birth Cohort Study of China Medical University in Shenyang

Обзор

The CMUBCS is a birth cohort study located in Shenyang, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental factors, family and lifestyle, clinical experimental outcomes and imaging results of pregnant women and children from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the children and their parents.

Подробное описание

Early life phase (fetal and infant) is a critical period for the development of health and disease in a person's life. Many adult chronic diseases, such as diabetes, cardiovascular and cerebrovascular diseases, all come from the exposure of negative environmental and behavioral factors during this period. By collecting the lifestyle data and clinical data of pregnant women at different periods, the appropriate indicators are anticipated to be selected to predict and evaluate the outcome of pregnancy and the health of the mothers and children in the long term. The status of overweight and obesity of children in Shenyang and its surrounding areas are anticipated to be analyzed by descriptive and etiological analysis through collecting the lifestyle data and clinical data of different periods of pregnant women and the lifestyle data of different developmental stages of children.

Первичные конечные точки

• Change of biometric parameter in centimeter of fetuses at the thirteenth week of gestational age [Срок оценки: At every week from the thirteenth week of gestational age to delivery of babies]
• Weight in kilogram of neonate [Срок оценки: At birth of neonate]
• Gene expression of husbands of pregnancy women [Срок оценки: At 13 weeks of gestational age]
• Change of gene expression of pregnancy women [Срок оценки: At 13, 26 and 34 weeks of gestational age]
• Result of Non-invasive Prenatal Testing [Срок оценки: From 12 to 22 weeks of gestational age]

Вторичные конечные точки (4)

• Change of intestinal flora during early childhood [Срок оценки: Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years]
• Height in centimeter changes during childhood [Срок оценки: Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years]
• Weight in kilogram changes during childhood [Срок оценки: Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years]
• Change of gene expression during childhood [Срок оценки: Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years]

Критерии участия

Критерии включения

• Pregnant women, <13 gestational weeks
• Permanent residents or families intended to remain in Shenyang and surrounding areas
• Pregnant women who are planned to be examined and delivered in Shengjing Hospital.

Критерии исключения

• Pregnant women who refuse to take part in the study
• Pregnant women have diseases that might affect the results of researches, including neuropsychiatric disorders.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Китай · 1 центр

• Shengjing Hospital — Шэньян

Публикации

• Zhang L, Du Y, Zhou J, Liu C, Li J, Qiao C. Timing of diagnostic workups in Chinese population with recurrent pregnancy loss: a cross-sectional study. BMC Pregnancy Childbirth. 2025 Mar 29;25(1):373. doi: 10.1186/s12884-025-07330-8. PMID 40158174

Идентификаторы

NCT: NCT03561766 · CMUBCS

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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