Chinese Second Hip Fracture Evaluation

Официальное название

Second Hip Fracture Evaluation in Chinese Elderly Patients Using Quantitative Computed Tomography

Обзор

1. To Compare overall rates of second hip fractures in both genders, 2. To determine the effect of hip fracture on proximal femoral volumetric bone mineral density (vBMD), bone structure and muscle by quantitative computed tomography(QCT), 3. To evaluate the contribution of QCT-image analysis to the prediction of the second hip fracture risk. 4. To identify the differences between femoral neck fracture and trochanter fracture following hip fracture

Подробное описание

Osteoporotic hip fracture is a great harm among elderly people, for whom disability and death often occurs. Furthermore, sustaining an osteoporotic hip fracture increases the risk of a subsequent fracture. However, the risk factors of subsequent hip fractures are less studied and the proximal femur bone structure and muscle changes following first hip fracture are little known.

Therefore, we propose to conduct an observational and perspective study to assess the effect of hip fracture on proximal femoral bone and muscle using quantitative computed tomography (QCT), as well as to evaluate the contribution of QCT-image analysis to the prediction of the second hip fracture risk. As hip fractures are divided into two major anatomic based types in clinical: femoral neck fractures (intracapsular) and trochanter fractures (extracapsular), the fundamental objective also includes identifying bone and muscle differences in a union activity between the two type fractures. Compared with duel-energy x-ray absorptiometry (DXA), QCT offers the advantage of selective measurement of the metabolically active and structurally important trabecular bone in the proximal femoral. Volumetric BMD and structure of proximal femoral and muscle around hip will be measured with QCT. The CT scanner will be the clinical CT scanner of the local participated center. Quality control and monitoring will be conducted by Beijing Jishuitan hospital, as well as the centralised image interpretation.

Первичные конечные точки

• Hip re-fracture [Срок оценки: 3 years]
• all cause death [Срок оценки: 2 year]

Критерии участия

Критерии включения

• a:Osteoporotic patients b:Osteoporotic hip fracture patients (femoral neck fracture and femoral trochanteric fracture) c: Be willing to and be able to join in the study and sighed the informed consent

Критерии исключения

• a:Under 47years old b:Non-surgical repair of hip fracture c:Pathologic fracture d:Violence-related trauma e:Bilateral hip implants or have hip replacement on the non-fractured side

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Китай · 1 центр

• Beijing ji shui tan hospital — Пекин

Публикации

• Ma Y, Ge Y, Guo Z, Su Y, Wang C, Wang Q, Wang L, Cheng X, Yang M, Yan D. Hip structural analysis parameters are not associated with the risk of postmenopausal female second hip fracture: a retrospective study. BMC Musculoskelet Disord. 2025 Mar 10;26(1):233. doi: 10.1186/s12891-025-08368-7. PMID 40065296

Идентификаторы

NCT: NCT03461237 · JST2016CSHFE

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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