Twins Born in Guangzhou
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: No intervention.
- Кому может быть актуально
- Состояния в реестре: Twin Diseases, Immune Development, Childhood Obesity, Host and Microbiome. Базовые параметры: до 18 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Китай
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Twins Born in Guangzhou Cohort Study
Обзор
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.
Подробное описание
Twins share the same intrauterine environment and the early family environment. When conducting research of chronic disease etiology, twins cohort can be a good control of bias from age, gender, genetic and early environment. Twin-based designs provide an estimate of the relative contribution of genetic and non-genetic factors to a specific phenotype. Twins study has an advantage of calculating heritability of traits. Since heritability of traits is various from different populations. It is important to establish database to calculate the heritability of traits associated with chronic major diseases in Chinese population. Twins cohort is rare in China at present. Therefore, extensive information including physical characteristics, mental health, and behaviors is collected from both twins and their parents. Longitudinal follow-up and surveillance of common diseases are also to be conducted. The 2-BIG aims to explore epigenetic markers and genes related to health status, as well as gene-environment interactions on diseases, both in intrauterine and childhood stages, especially in Chinese population.
Вмешательства
- Другое No intervention
Первичные конечные точки
- Neurodevelopment at early childhood [Срок оценки: At age of 1 year old]
- Intelligence quotient [Срок оценки: At age of 6 years old]
- Change of gene expression during childhood [Срок оценки: Age at 1 year , 6 years, 12years and 18years]
Вторичные конечные точки (4)
- Change of intestinal flora during early childhood [Срок оценки: Age at 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years]
- Changes of body composition and bone density during early childhood [Срок оценки: At birth, age of 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years]
- Height in kilometer changes during childhood [Срок оценки: At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year]
- Weight in kilogram changes during childhood [Срок оценки: At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year]
Критерии участия
Критерии включения
- Live twins delivered in Guangzhou Women and Children's Medical Center
- Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years
- Baseline information during pregnancy available
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Китай · 1 центр
- Guangzhou Women and Children's Medical Center — Гуанчжоу
Публикации
- Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20. PMID 28321694
Идентификаторы
NCT: NCT03331133 · 2017060803