Immune Responses in Health Care Personnel
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: influenza vaccine.
- Кому может быть актуально
- Состояния в реестре: Influenza. Базовые параметры: 18 лет — 64 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Финляндия
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Immune Responses to Influenza Vaccinations and Viruses Among Health Care Personnel
Обзор
This is an investigator-initiated 10 year long open cohort observational study, aiming to increase the understanding of the humoral and cellular immunological mechanisms of vaccination against influenza, including effects of repeated vaccination, the duration of protection, immunity against circulating viruses, as well as factors affecting the immunological responses and immunity against other vaccine preventable infectious diseases among health care personnel.
Подробное описание
Influenza vaccination is given according to the normal routine of Hospital District of Helsinki and Uusimaa (HUS) occupational health care. Blood samples will be collected before vaccination, 5 weeks after vaccination and 6 months after vaccination. Both the same participants and also new participants will be recruited each year. The analysis will be mainly descriptive.
Вмешательства
- Биопрепарат influenza vaccine
Vaccine for prevention of influenza. Vaccines change by influenza season.
Первичные конечные точки
- Humoral immunity against each present season's vaccine and circulating influenza strains [Срок оценки: 10 years]
Вторичные конечные точки (3)
- Humoral immunity against previous seasons' vaccine and circulating influenza strains [Срок оценки: 10 years]
- Cellular immunity against current and previous seasons' vaccine and circulating influenza strains [Срок оценки: 10 years]
- Effect of repeated vaccination against influenza [Срок оценки: 10 years]
Критерии участия
Критерии включения
- Members of health care or laboratory personnel in HUS having decided to take the seasonal influenza vaccination by the routine occupational health care service
- General good health as established by or volunteer's own statement
- Written informed consent
- Presumably able and willing to participate in the study during the starting influenza season
Критерии исключения
- Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection.
- Administration (longer than 14 days) of immunosuppressants or other immune- modifying drugs within 6 months before the vaccination; oral corticosteroids in dosages of 20 mg/day or more prednisolone or equivalent are excluded; inhaled or topical steroids are allowed.
- Pregnancy or lactation
- Acute disease at the time of enrolment (defined as the presence of a moderate or severe illness with or without fever)
- Contraindication for influenza vaccination
- Any other criteria which, in the investigator's or dedicated study staff member's opinion, would compromise the ability of a subject to participate in the study, a subject's well-being, or the outcome of the study
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Да
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Финляндия · 1 центр
- The Hospital District of Helsinki and Uusimaa — Helsinki
Идентификаторы
NCT: NCT03323112 · FinFLU_HCPimmu_2017THL