Cognitive Training Intervention and Attitudes Towards Genetics
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- В протоколе указаны: Lumosity, Lumosity (waitlist control).
- Кому может быть актуально
- Состояния в реестре: Cognitive Impairment, Hematologic Neoplasms, Hematopoietic Cell Transplant. Базовые параметры: от 21 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- США
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
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Официальное название
Intervention Strategies to Improve Cognitive Functioning in Hematologic Cancer Survivors After Hematopoietic Cell Transplantation
Обзор
A pilot study to evaluate feasibility of enrollment of patients in an intervention to improve neurocognitive function in hematopoietic cell transplantation (HCT) survivors using the cognitive training Lumosity program. In addition, patients' interest in receiving information regarding genetic risk of cognitive impairment post-HCT will be measured.
Подробное описание
The investigators propose using an "off-the-shelf" product - Lumosity (http://www.lumosity.com/) - an online cognitive training program, to address the cognitive impairment in outpatient HCT survivors. The program offers over 60 tasks in game-like format that cover the main cognitive domains: processing speed, working memory, and executive function. Training will involve a daily session of 5 training tasks for 12 weeks. Each time the patient is logged in for a session, a customized report will be generated by the Lumosity program to capture performance information.
Ideally, targeting the intervention and offering it specifically to those at highest risk (integrating clinical and genetic markers) would ensure efficacy. However, evidence is lacking on whether patients are receptive to communication of individual genetic information and whether provision of such results would lead to enhanced intervention response. To realize the high expectations of personalized medicine, patients' preferences and attitudes need to be thoroughly investigated especially as more information on genetic risk becomes available. The investigators will examine patients' genetic knowledge to determine whether factual knowledge of genetics is essential for understanding genetic risk and for informing treatment decision making in this patient population.
Вмешательства
- Поведенческое Lumosity
Computer-based online cognitive training program using the Lumosity cognitive training program. - Поведенческое Lumosity (waitlist control)
Computer-based online cognitive training program using the Lumosity cognitive training program. The control group will receive the intervention after a waiting period of 12 weeks.
Первичные конечные точки
- Number of HCT patients completing the 2-arm wait-listed randomized trial of cognitive training intervention for a period of 3 months [Срок оценки: 12 weeks]
- Change in cognitive function between intervention and wait list control arms from baseline to 12 weeks. [Срок оценки: Baseline to 12 weeks]
Вторичные конечные точки (5)
- 16-item survey to measure genetic factual knowledge at baseline [Срок оценки: Baseline]
- Effect size of associations of key predictors with genetic factual knowledge at baseline [Срок оценки: Baseline]
- 5 Likert scale survey questionnaire to measure importance of receiving genetic risk information [Срок оценки: baseline]
- 5 Likert scale survey questionnaire to measure impact of receiving genetic risk information on intervention uptake [Срок оценки: baseline]
- 5 Likert scale survey questionnaire to measure impact of receiving genetic risk information on intervention adherence [Срок оценки: baseline]
Критерии участия
Критерии включения
- ≥ 21 years old at time of allogeneic HCT performed at UAB
- Outpatient and between 3 and 6 months post HCT
- English speaking
- Possess access to an internet-connected home computer
Критерии исключения
- History of pre-existing neurological disorder or documented major psychiatric disorder; significant auditory, visual, or motor impairments
- Participated in neuropsychological intervention within the past 6 months
- History of color blindness
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Здоровые добровольцы: Нет
Дизайн исследования
- Распределение
- Рандомизированное
- Модель
- Параллельные группы
- Маскирование
- Открытое
- Основная цель
- Поддерживающая терапия
Центры проведения
США · 1 центр
- University of Alabama at Birmingham — Birmingham
Идентификаторы
NCT: NCT03094026 · X161221006