Идёт набор NCT02811653

Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease

Без фазы С лечением Alzheimer Disease

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: Brain MRI, neuropsychological evaluation, Blood.
Кому может быть актуально: Состояния в реестре: Alzheimer Disease. Базовые параметры: 40 лет — 85 лет · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: Франция
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

In AD (Alzheimer disease), the anatomic correlates of attention disorders (as evaluated by motor slowing) have not been thoroughly characterized.

median SRT (simple reaction time) to a stimulus (in milliseconds) [Срок оценки: Day 0]

Age between 40 and 85
French mother tongue
Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
MCI, according to Albert et al.'s criteria (Albert et al., 2011)
Mild dementia (MMSE>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
Social security coverage
Healthy controls

Healthy age and gender matched volunteers will be recruited into the study from the general population.

Reading or writing difficulties related to a learning disorder or illiteracy.
A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):

NYHA stage IV dyspnoea.
respiratory impairment requiring oxygen therapy.
liver impairment.
kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:

stroke.
meningitis or encephalitis.
severe head injury.
sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
epilepsy (requiring ongoing treatment),
psychiatric disorders (other than treated depression).
treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.
Impossibility to perform a neuropsychological evaluation or brain MRI.
Withdrawal from the study at any time, if desired.
Pregnancy
Contra-indication to MRI: