TURKAPNE - The Turkish Sleep Apnea Database: A National, Multicenter, Observational, Prospective Cohort Study

Обзор

Primary aim of the TURKAPNE (The Turkish Sleep Apnea Database) study is to generate a cross-sectional nationwide database to define clinical and polysomnographic characteristics of the sleep apnea patients in Turkey. Associations of phenotypes of sleep apnea patients with metabolic and cardiovascular diseases as well as risk for traffic accidents will be explored as secondary aims. Impact of treatment of sleep apnea on metabolic and cardiovascular complications as well as compliance with positive airway pressure treatment will be further explored longitudinally.

Подробное описание

All subjects undergoing sleep study for suspicion of obstructive sleep apnea will be registered in a web-based national database regarding:

* Anthropometric data, educational status, driving licence, * Smoking and alcohol use * Comorbidities, and drug use * Questionnaires, excessive daytime sleepiness * Polygraphic and polysomnographic findings * Blood pressure measurements * If taken, blood glucose, lipids and other biochemical markers * If measured, lung function test results * If measured, echocardiography findings * Follow-up data regarding treatment modality and compliance

Вмешательства

• Устройство Positive Airway Pressure (PAP)
  Treatment of OSA with PAP
• Устройство Intraoral device (IOD)
  Treatment of OSA with IOD
• Процедура Uvuloplasty
  Uvuloplasty
• Другое Conservative treatment
  No active intervention

Первичные конечные точки

• Metabolic and cardiovascular diseases in obstructive sleep apnea phenotypes [Срок оценки: Up to three years]

Вторичные конечные точки (3)

• Sex differences in obstructive sleep apnea phenotypes [Срок оценки: Up to three years]
• Adherence to positive airway pressure treatment in obstructive sleep apnea [Срок оценки: Through study completion, an average of 7 years]
• Incidence of cardiovascular diseases and mortality [Срок оценки: Through study completion, an average of 7 years]

Критерии участия

Критерии включения

• Consecutive adult patients undergoing sleep study for suspicion of obstructive sleep apnea
• Ability to read and speak
• Signed informed consent.

Критерии исключения

• subjects who use positive airway pressure
• subjects with limited life expectancy due to advanced renal disease or uncontrolled malignancies
• subjects with alcohol dependency

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Turkey (Türkiye) · 1 центр

• Koç University Hospital — Istanbul

Публикации

• Peker Y, Basoglu OK, Firat H; TURKAPNE Study Group. Rationale and Design of the Turkish Sleep Apnea Database - TURKAPNE: A National, Multicenter, Observational, Prospective Cohort Study. Turk Thorac J. 2018 Jul;19(3):136-140. doi: 10.5152/TurkThoracJ.2018.18097. Epub 2018 Jul 1. PMID 30083405
• Gurkan CG, Pihtili A, Kiyan E, Tasbakan MS, Basoglu OK, Arbatli S, Aydin S, Cilli A, Dursunoglu N, Baran B, Peker Y; Turkapne Study Group. Diabetes mellitus is associated with increased prevalence and severity of COMISA: evidence from the nationwide TURKAPNE cohort. J Clin Sleep Med. 2026 Jul 2;22(1):103. doi: 10.1007/s44470-026-00109-4. PMID 42390661
• Pihtili A, Kiyan E, Balcan B, Arbatli S, Cilli A, Altintas N, Ugurlu AO, Gurkan CG, Tasbakan MS, Dursunoglu N, Ogun H, Annakkaya AN, Sokucu SN, Firat H, Basoglu OK, Peker Y; Turkapne Study Group. Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort. Sleep Med. 2025 Feb;126:228-234. doi: 10.1016/j.sleep.2024.12.018. PMID 39721358

Идентификаторы

NCT: NCT02784977 · 09.2016.311

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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