Идёт набор NCT02747888

Hereditary Risk Factors for Thyroid Cancer

Без фазы С лечением Thyroid Cancer

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают: В протоколе указаны: •Referral to Genetic Counselor, if indicated.
Кому может быть актуально: Состояния в реестре: Thyroid Cancer. Базовые параметры: Без ограничений · Все.
Что важно проверить: Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится: США
Следующий шаг: Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →

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Обзор

Thyroid cancers can occur sporadically, but can also be found as tumors that cluster in families with other cancers or genetic syndromes. Researchers are studying thyroid cancer in children and families, with a particular interest in understanding genes and other factors that may put individuals at risk for developing thyroid cancer and thyroid nodules. * In this study, family and medical history information is collected alongside a blood or saliva sample for genetic studies. * Individuals with a past or present childhood thyroid cancer/nodule or a thyroid cancer suspected to be inherited in their family are invited to participate.

Подробное описание

The purpose of this research study is to learn more about risk factors for inherited thyroid cancer.

The investigators would like to use the participant DNA to look for alterations in genes. The investigator will perform DNA sequencing and other genetic studies to identify errors in the genes that may contribute to the formation of thyroid nodules and cancer.

Вмешательства

Генная терапия •Referral to Genetic Counselor, if indicated

Первичные конечные точки

Number of participants who have childhood or suspected familial thyroid nodules/cancer [Срок оценки: 2 years]
Number of germline mutations identified associated with thyroid cancer predisposition [Срок оценки: 2 years]
Prevalence of suspected familial thyroid cancer among those with childhood thyroid nodules/cancer [Срок оценки: 2 years]

Критерии участия

Критерии включения

Individual pediatric patient with current or previous known or suspected thyroid cancer or nodule(s).
Individual adult patient with current or previous known or suspected thyroid cancer or nodule(s) if they come from a family with a high suspicion of hereditary cancer (as below).
Individuals from families with a high suspicion of hereditary thyroid cancer:

Families with a current or previous diagnosis of a thyroid cancer/nodule occurring in childhood (<18 years old).
Families with a high suspicion of hereditary thyroid cancer/nodules other than above to include:

Families with thyroid cancer in multiple individuals
Families with thyroid cancer and a known genetic syndrome
Families with thyroid cancer and a suspected genetic syndrome (e.g. multiple childhood cancers in the family, multiple primary cancers, multiple endocrinopathies, etc.)