Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

Официальное название

Tissue Procurement For Hematolymphoid Conditions

Обзор

RATIONALE: Collecting and storing samples of tissue, blood, and body fluid from patients with cancer to study in the laboratory may help the study of cancer in the future. PURPOSE: This research study is collecting and storing blood and tissue samples from patients being evaluated for hematologic cancer.

Подробное описание

OBJECTIVES:

* Provide source of patient tissue, blood, and body fluid samples for ongoing diagnostic, prognostic, or immune-monitoring studies. * Support and enhance translational, clinical and basic research for Lineberger Comprehensive Cancer Center (LCCC) members (and non-members who have an LCCC member as sponsor and collaborator) with IRB-approved studies. * Maintain responsible and appropriate policies and procedures that ensure good patient care and responsible conduct of research. * Address medical and legal issues, and protect participant and patient privacy and confidentiality. * Provide a responsible and uniform mechanism for the integrated coordination of the hemato-pathologist and surgeon or hematology/oncology staff, researcher, and protocol office to obtain appropriate specimens for researchers. * Support young investigators to obtain pilot data for grant funding.

OUTLINE: Patients undergo tissue, blood, and body fluid collection during diagnostic or routine procedures for future correlative studies. Tissue samples may include, but are not limited to, lymph node or non-nodal biopsies, bone marrow biopsy and/or aspirate, blood and serum, and buccal swabs for germline DNA analysis.

Вмешательства

• Другое biologic sample preservation procedure
  All samples collected during routine clinical care.
• Другое cytology specimen collection procedure
  All Samples collected during routine clinical care.

Первичные конечные точки

• Tissue, blood, and body fluid samples collection for ongoing diagnostic, prognostic, or immune-monitoring studies [Срок оценки: 30 years]
• Development of a centralized, quality-controlled, quality-assured facility for the procurement, processing, storage, and distribution of normal and malignant tissue specimens and corresponding blood specimens [Срок оценки: 30 years]

Критерии участия

DISEASE CHARACTERISTICS:

• Diagnosis of abnormal hematopoietic/lymphoid cancer, including any of the following:

• Acute myeloid leukemia
• Acute lymphoblastic leukemia
• Chronic myelogenous leukemia
• Chronic lymphoid leukemia
• Non-Hodgkin lymphoma
• Hodgkin lymphoma
• Myelodysplastic syndromes
• Myeloproliferative disorders
• Multiple myeloma
• Waldenstrom macroglobulinemia
• Aplastic anemia
• Any other diseases that generate abnormalities in either number, function, or both of any cell type of hematolymphoid lineage
• Patients who are being evaluated at the hematology/oncology clinics of the University of North Carolina Hospitals, at the stem cell transplant clinic, or in the hospital

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Нет

Дизайн исследования

Модель наблюдения

Другое

Центры проведения

США · 1 центр

• Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill

Идентификаторы

NCT: NCT01137643 · LCCC 0824 · P30CA016086 · CDR0000674072

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

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