Hyaluronic Acid vs I-PRF With Microneedling in Enhancing Peri-implant Soft Tissue
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Hyaluronic Acid (HA), Platelet rich fibrin.
- Who it may be relevant to
- Registry conditions: Peri-implant Mucosa Thickness. Basic parameters: 21 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Hyaluronic Acid Versus I-PRF Combined With Microneedling for Peri Implant Soft Tissue Enhancement: A Randomized Controlled Clinical Trial
Overview
This study aims to compare the use of microneedling alone versus with hyaluronic acid or i-PRF in conjunction with microneedling in peri-implant mucosa in the esthetic zone to test the superior increase in gingival thickness.
Detailed description
Despite the rising demand for esthetics and the prevailing use of dental implants in the recent era, the soft tissue remains a dilemma that affects patients' satisfaction and the implants' longevity in the oral environment, especially in the esthetic region of the maxilla. Various studies have been done to test the effectiveness of microneedling, hyaluronic acid, and i-PRF as alternative non-invasive or minimally invasive methods targeting tissue enhancement in the gingiva, and have proven that they have notable and desirable results. However, there is a lack in the literature regarding the use of these previously mentioned treatment options with regard to peri-implant soft tissue, and which of the delivered solutions offers superior results with reference to peri-implant mucosa in conjunction with microneedling.
Interventions
- Drug Hyaluronic Acid (HA)
Hyaluronic acid (HA) is a genuine linear glycosaminoglycan that is present within the extracellular matrix of connective, epithelial, and neural tissues. - Biological Platelet rich fibrin
Injectable PRF (i-PRF) is a notable method in enhancing soft tissue phenotypes, relying on its injectable form that can be well delivered to targeted areas to ensure proper distribution of growth factors and cytokines.
Primary outcome measures
- Peri-implant gingival thickness [Time frame: 6 months]
Eligibility criteria
Inclusion criteria
- Patients with delayed implants placed in the maxillary esthetic region in correct positioning and angulation
- Patients with peri-implant gingival thickness ≤ 1 mm
- Patients with healthy gingiva and who can maintain good oral hygiene around implants
Exclusion criteria
- Marginal bone loss ≤ 2 mm
- Patients with peri-implantitis or periodontitis
- Patients with systemic conditions or diseases impairing healing or soft tissue metabolism
- Pregnant or lactating females
- Patients taking medications affecting the gingiva
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07750756 · 1673