Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Preconditioning with control ischemic episodes.
- Who it may be relevant to
- Registry conditions: Hemodialysis, Ischemia Preconditioning, Chronic Kidney Disease, Blood Pressure Disorders. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Poland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The aim of our study is to evaluate the impact of repeated episodes of ischemic quenching on changes in blood pressure, heart rate and laboratory parameters of inflammation in patients with kidney diseases. There is credible evidence that intentionally producing periods of ischemia provides protection of the myocardium and blood vessels against subsequent ischemic injury. The examination will be performed during hospitalization in the Department of Nephrology, Hypertension, Transplantology and Internal Diseases and will last 4 days. On the first day, blood pressure will be measured using an automatic blood pressure monitor, radial artery pulse, blood saturation will be measured using a pulse oximeter, and approximately 6 ml of venous blood will be collected from the elbow bend area for laboratory tests. Then, compression of the lower limb below the knee will be performed using a blood pressure cuff. Four 5-minute cycles of inflation and deflation of the cuff will be performed. The pressure on the lower limb will be repeated on the next two days. On the last day of the examination, blood pressure, heart rate and blood saturation will be measured again, and approximately 6 ml of venous blood will be collected again for laboratory tests.
Interventions
- Other Preconditioning with control ischemic episodes
4 cycles of 5-minute inflation and deflation using a sphygmomanometer cuff at a pressure of 30 mmHg above the systolic value through three consecutive days
Primary outcome measures
- Assessment of changes of parameter: Measurement of SIRT-1 [ng/] [Time frame: 7 days]
- Assessment of changes of parameter blood saturation [%]. [Time frame: 7 days]
- Assessment of IL-6 [Time frame: 7 days]
- Assessment of Blood pressure [Time frame: 7 days]
- Assessment of heart beat/min [Time frame: 7 days]
Eligibility criteria
Inclusion criteria
- obtaining the patient's voluntary, informed consent to participate in the experiment,
- chronic kidney disease in stages G1-G5,
- women and men over 18 years of age.
- failure to meet the qualification criteria for participation in the study,
- consciousness disorders,
- heart failure (NYHA IV),
- severe anemia (Hb concentration<8g/dL),
- features of muscle cell damage (e.g. rhabdomyolysis),
- peripheral circulation disorders, peripheral vascular diseases.
Exclusion criteria
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Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
Poland · 2 centers
- Medical University of Lodzi — Lodz
- Medical University of Lodzi — Lodz
Publications
- Jia P, Ji Q, Zou Z, Zeng Q, Ren T, Chen W, Yan Z, Shen D, Li Y, Peng F, Su Y, Xu J, Shen B, Luo Z, Wang C, Ding X. Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial. Circulation. 2024 Oct 22;150(17):1366-1376. doi: 10.1161/CIRCULATIONAHA.124.071408. Epub 2024 Sep 25. PMID 39319450
- Lang JA, Kim J. Remote ischaemic preconditioning - translating cardiovascular benefits to humans. J Physiol. 2022 Jul;600(13):3053-3067. doi: 10.1113/JP282568. Epub 2022 May 31. PMID 35596644
- Przyklenk K, Whittaker P. Remote ischemic preconditioning: current knowledge, unresolved questions, and future priorities. J Cardiovasc Pharmacol Ther. 2011 Sep-Dec;16(3-4):255-9. doi: 10.1177/1074248411409040. PMID 21821525
Identifiers
NCT: NCT07746102 · ISP1