Impact of Linked Color Imaging on Sessile Serrated Lesion Miss Rate
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: WLI Then LCI Withdrawal, LCI Then WLI Withdrawal.
- Who it may be relevant to
- Registry conditions: Colorectal Sessile Serrated Lesion. Basic parameters: from 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Impact of Linked Color Imaging on Sessile Serrated Lesion Miss Rate: a Multicenter Tandem Rondomized Controlled Trial
Overview
This prospective, multicenter randomized controlled trial aimed to investigate whether linked color imaging (LCI) could reduce the miss rate of sessile serrated lesions (SSLs) during tandem colonoscopy compared with conventional white-light imaging (WLI).
Interventions
- Procedure WLI Then LCI Withdrawal
Patients in the WLI then LCI withdrawal group first underwent careful endoscopic inspection with white-light imaging (WLI). The endoscopic setting was then switched to linked color imaging (LCI) for the second withdrawal. All polyps detected during both inspection passes were resected, and the number of lesions missed on the first withdrawal was subsequently calculated. - Procedure LCI Then WLI Withdrawal
Patients in the LCI then WLI withdrawal group first underwent careful endoscopic inspection with linked color imaging (LCI). The endoscopic setting was then switched to white-light imaging (WLI) for the second withdrawal. All polyps detected during both inspection passes were resected, and the number of lesions missed on the first withdrawal was subsequently calculated.
Primary outcome measures
- sessile serrated lesions miss rate(SSLMR) [Time frame: One day]
Secondary outcome measures (7)
- adenoma miss rate (AMR) [Time frame: One day]
- advanced adenomas miss rate (AAMR) [Time frame: One day]
- polyps miss rate (PMR) [Time frame: One day]
- sessile serrated lesions detection rate (SSLDR) [Time frame: One day]
- adenomas detection rate (ADR) [Time frame: One day]
- advanced adenomas detection rate (AADR) [Time frame: One day]
- polyps detection rate (PDR) [Time frame: One day]
Eligibility criteria
Inclusion criteria
- Subjects aged ≥45 years, regardless of gender;
- Subjects undergoing screening colonoscopy;
- Subjects with no prior colonoscopy;
- Voluntarily provide written informed consent.
Exclusion criteria
- Subjects unable to cooperate with or tolerate colonoscopy;
- Subjects with inflammatory bowel disease;
- Known or highly suspected colorectal obstruction;
- History of colorectal surgery;
- Chronic recurrent constipation;
- Failure to discontinue anticoagulants or antiplatelet agents for at least 1 week before the procedure;
- Poor bowel preparation with an inadequate Aronchick scale score during colonoscopy;
- Failed cecal intubation;
- High-risk conditions including severe cardiovascular and cerebrovascular diseases, uncorrected severe anemia or active infection;
- Pregnant or breastfeeding women;
- Subjects deemed ineligible for participation in this trial at the investigator's discretion.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Single blind
- Primary purpose
- Diagnostic
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07745842 · NFEC-2026-304