Tracking Risk in Adolescents and Children for Early Identification of Common Mental Disorders
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: High Risk, Depression / Major Depressive Disorder, Anxiety Disease, Obsessive - Compulsive Disorder. Basic parameters: 7 years — 17 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Longitudinal Study for Risk Identification of Common Mental Disorders in High-Risk Children and Adolescents
Overview
This prospective observational cohort study will enroll approximately 200 children and adolescents aged 7-17 years who are at elevated risk for common mental disorders, including depressive disorders, anxiety disorders, and obsessive-compulsive disorder, based on family history or subthreshold emotional or behavioral symptoms. Participants will be followed for two years. Clinical assessments, questionnaires, EEG, biological samples, and MRI will be collected at scheduled intervals. The study aims to identify factors associated with the onset and progression of these disorders and support early risk identification.
Primary outcome measures
- Cumulative Incidence of Depressive Disorders, Anxiety Disorders, or Obsessive-Compulsive Disorder [Time frame: From baseline through 24 months]
Secondary outcome measures (1)
- Time to Onset of a Depressive Disorder, Anxiety Disorder, or Obsessive-Compulsive Disorder [Time frame: From baseline through 24 months]
Eligibility criteria
Inclusion criteria
- Aged 7-17 years at enrollment.
- Meeting at least one of the following conditions: Having at least one first-degree relative with a depressive disorder, anxiety disorder, or obsessive-compulsive disorder; or exhibiting clinically relevant but subthreshold depressive, anxiety, obsessive-compulsive, or repetitive behavioral symptoms.
- Not meeting the full diagnostic criteria for a depressive disorder, anxiety disorder, or obsessive-compulsive disorder at baseline, as assessed using the K-SADS-PL.
- Willing and able to participate in the scheduled assessments and follow-up visits.
- Written informed consent provided by a parent or legal guardian and assent provided by the participant
Exclusion criteria
- A current or previous diagnosis of a depressive disorder, anxiety disorder, or obsessive-compulsive disorder.
- A severe psychiatric condition requiring immediate clinical intervention, including acute suicide risk, a psychotic disorder, or a bipolar disorder.
- A major neurological disorder, severe head injury, or serious or unstable medical condition that may interfere with study participation.
- Intellectual or cognitive impairment that prevents the participant from understanding or completing the study assessments.
- Inability or unwillingness of the participant or legal guardian to comply with the study procedures.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Shanghai Mental Health Center — Shanghai
Identifiers
NCT: NCT07744490 · SMHC-HRP-001