Relationship Between Frontal QRS-T Angle and Collateral Circulation in Coronary Artery Chronic Total Occlusion
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: 12-lead Electrocardiogram (ECG) and Coronary Angiography.
- Who it may be relevant to
- Registry conditions: Chronic Total Occlusion (CTO), Frontal QRS-T Angle. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Frontal QRS-T Angle as an Electrocardiographic Marker for Collateral Circulation in Coronary Artery Chronic Total Occlusion
Overview
• Aim of the work: To examine the relationship between collateral circulation and the frontal QRS-T angle in patients with chronic total occlusion (CTO)
Detailed description
i. Study Objectives
1. Primary Objective:
• To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO). 2. Secondary Objectives:
* To identify other independent clinical and laboratory predictors (such as serum albumin levels and neutrophil counts) associated with an increased frontal QRS-T angle in patients with CTO. * To compare echocardiographic parameters (such as left ventricular ejection fraction and left ventricular dimensions) between patients with a normal QRS-T angle and those with an increased QRS-T angle.
Interventions
- Diagnostic test 12-lead Electrocardiogram (ECG) and Coronary Angiography
A 12-lead ECG is performed to calculate the frontal QRS-T angle, and coronary angiography is performed to evaluate the coronary collateral circulation using the Rentrop Classification.
Primary outcome measures
- correlation between frontal QRS-T angle and collateral circulation in CTO patients [Time frame: baseline ( at the time of the diagnosis )]
Eligibility criteria
Inclusion criteria
- Patients undergoing diagnostic coronary angiography due to stable angina persisting for a minimum duration of three months.
- Patients diagnosed with total occlusion in at least one coronary artery, assessed to have chronic total occlusion (CTO) based on clinical and angiographic findings.
Exclusion criteria
- Patients presenting with malignancies, atrial fibrillation, connective tissue disorders, hepatic failure, or renal failure.
- A documented history of cardiac pacemaker implantation, prior bypass surgeries, or surgical valve replacements.
- Congenital heart anomalies.
- Patients receiving pharmacological interventions that affect ventricular repolarization (other than beta-adrenergic antagonists).
- Individuals exhibiting abnormal electrolyte levels at the time of admission.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Egypt · 1 center
- AssiutU — Asyut
Publications
- Ozturk M, Emlek N, Ozyildiz AG, Ergul E, Durak H, Ozyildiz A, Cetin M. The Relationship Between Collateral Circulation and Electrocardiographic Frontal QRS-T Angle in Patients with Coronary Artery Chronic Total Occlusion. J Clin Med. 2025 Dec 24;15(1):148. doi: 10.3390/jcm15010148. PMID 41517395
- Sawant AC, Bhardwaj A, Srivatsa S, Sridhara S, Prakash MPH, Kanwar N, Rodriguez J, Tse G, Liu T, Kumar A, Beck H, Srivatsa SS. Prognostic value of frontal QRS-T angle in predicting survival after primary percutaneous coronary revascularization/coronary artery bypass grafting for ST-elevation myocardial infarction. Indian Heart J. 2019 Nov-Dec;71(6):481-487. doi: 10.1016/j.ihj.2019.09.008. Epub 201 PMID 32248922
- Attar A, Sayadi M, Hosseinpour A, Brilakis ES, Mehdizade F, Namvar Z, Khosravi A, Boshtam M, Noohi F, Assareh A, Kazemi T, Farshidi H, Khaledifar A, Abbaszadeh M, Sarrafzadegan N. Prevalence and Clinical Parameters Associated With Chronic Total Occlusions in Patients With Chronic Coronary Syndromes: Insights From a Nationwide Registry. Health Sci Rep. 2025 Mar 18;8(3):e70583. doi: 10.1002/hsr2.705 PMID 40109697
Identifiers
NCT: NCT07743437 · QRS-T Angle in CTO Patients